دورية أكاديمية
Combining thrombopoietin receptor agonists with immunosuppressive drugs in adult patients with multirefractory immune thrombocytopenia, an update on the French experience.
| العنوان: | Combining thrombopoietin receptor agonists with immunosuppressive drugs in adult patients with multirefractory immune thrombocytopenia, an update on the French experience. |
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| المؤلفون: | Crickx, Etienne, Ebbo, Mikael, Rivière, Etienne, Souchaud-Debouverie, Odile, Terriou, Louis, Audia, Sylvain, Ruivard, Marc, Asli, Bouchra, Marolleau, Jean-Pierre, Méaux-Ruault, Nadine, Gerfaud-Valentin, Mathieu, Audeguy, Philippe, Hamidou, Mohamed, Corm, Selim, Delbrel, Xavier, Fontan, Jean, Lebon, Delphine, Mausservey, Christelle, Moulis, Guillaume, Limal, Nicolas, Michel, Marc, Godeau, Bertrand, Mahévas, Matthieu |
| المساهمون: | Université de Lille, Inserm, CHU Lille, CHU Henri Mondor Créteil, Immunogenetics of pediatric autoimmune diseases Equipe Inserm U1163, Hôpital de la Timone CHU - APHM TIMONE, Hôpital Haut-Lévêque CHU Bordeaux, Centre hospitalier universitaire de Poitiers = Poitiers University Hospital CHU de Poitiers, Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286, CHU Dijon, CHU Clermont-Ferrand, Clinique de la Sauvegarde Lyon, CHU Amiens-Picardie, Centre Hospitalier Régional Universitaire de Besançon CHRU Besançon, Hôpital de la Croix-Rousse CHU - HCL, Centre Hospitalier Eure-Seine - Hôpital d'Evreux - Vernon (Evreux), Centre hospitalier universitaire de Nantes CHU Nantes, Centre hospitalier de Pau, HEMATIM - Hématopoïèse et immunologie - UR UPJV 4666 HEMATIM, Centre Hospitalier Chalon-sur-Saône William Morey, Centre Hospitalier Universitaire de Toulouse CHU Toulouse, Institut Necker Enfants-Malades INEM - UM 111 (UMR 8253 / U1151) |
| سنة النشر: | 2024 |
| المجموعة: | LillOA (Lille Open Archive - Université de Lille) |
| مصطلحات موضوعية: | combination therapy, immunosuppressive drug, ITP, TPO-RA |
| الوصف: | Combining drugs could be an effective option for treating multirefractory ITP, that is, patients not responding to rituximab, thrombopoietin receptor agonists (TPO-RA) and splenectomy. We conducted a retrospective, multicenter, observational study including multirefractory ITP patients who received a combination of a TPO-RA and an immunosuppressive drug. We included 39 patients (67% women, median age 59 years [range 21-96]), with a median ITP duration of 57 months [3-393] and a median platelet count at initiation of 10 × 109 /L [1-35]. The combination regimen was given for a median duration of 12 months [1-103] and included eltrombopag (51%) or romiplostim (49%), associated with mycophenolate mofetil (54%), azathioprine (36%), cyclophosphamide (5%), cyclosporin (3%) or everolimus (3%). Overall, 30 patients (77%) achieved at least a response (platelet count ≥30 × 109 /L and at least doubling baseline during at least 3 months), including 24 complete responses (platelet count >100 × 109 /L during at least 3 months) with a median time to response of 30 days [7-270] and a median duration of response of 15 months [4-63]. Severe adverse event related to ITP treatment was observed in 31%. In conclusion, this study confirms that some patients with multirefractory ITP can achieve long lasting response with this combination. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/rdf+xml; charset=utf-8; application/pdf |
| اللغة: | English |
| العلاقة: | British Journal of Haematology; Br J Haematol; http://hdl.handle.net/20.500.12210/100564Test |
| الإتاحة: | https://doi.org/20.500.12210/100564Test https://hdl.handle.net/20.500.12210/100564Test |
| حقوق: | Attribution-NonCommercial-NoDerivs 3.0 United States ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.F3A88B13 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |