دورية أكاديمية
Ablation of atrial fibrillation and dementia risk reduction during long-term follow-up: a nationwide population-based study
| العنوان: | Ablation of atrial fibrillation and dementia risk reduction during long-term follow-up: a nationwide population-based study |
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| المؤلفون: | Li, Guan-Yi, Chen, Yun-Yu, Lin, Yenn-Jiang, Chien, Kuo-Liong, Hsieh, Yu-Cheng, Chung, Fa-Po, Lo, Li-Wei, Chang, Shih-Lin, Chao, Tze-Fan, Hu, Yu-Feng, Lin, Chin-Yu, Chen, Shih-Ann |
| المساهمون: | Ministry of Science and Technology of Taiwan, TVGH, Research Foundation of Cardiovascular Medicine, Szu-Yuan Research Foundation of Internal Medicine |
| المصدر: | Europace ; volume 25, issue 5 ; ISSN 1099-5129 1532-2092 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2023 |
| الوصف: | Aims This study investigated the epidemiological characteristics of new-onset dementia in patients with atrial fibrillation (AF) and the association of catheter ablation with different subtypes of dementia. Methods and results We conducted a population-based, retrospective cohort study using data from the Taiwan National Health Insurance Research Database. In total, 136 774 patients without a history of dementia were selected after 1:1 propensity score matching based on age (with AF vs. without AF). A competing risk model was used to investigate the three subtypes of dementia: Alzheimer’s disease, vascular dementia, and other/mixed dementia. Inverse probability of treatment weighting (IPTW) was performed to minimize the impact on dementia risk due to the imbalanced baseline characteristics. After a median follow-up period of 6.6 years, 8704 events of new-onset dementia occurred. Among all AF patients developing dementia, 73% were classified as having Alzheimer’s disease, 16% as having vascular dementia, and 11% as having other/mixed dementia. The cumulative incidence of dementia in AF patients was higher than those without AF (log-rank test: P < 0.001 for both before and after IPTW). In patients with AF undergoing catheter ablation, the total dementia risk decreased significantly [P = 0.015, hazard ratio (HR): 0.74, 95% confidence interval (CI): 0.58–0.94] after multivariable adjustment, but not for the subtype of vascular dementia (P = 0.59, HR: 0.86, 95% CI: 0.49–1.50). Conclusion Patients with AF have a higher incidence of all types of dementia, including Alzheimer’s disease, vascular dementia, and a mixed type of dementia. Alzheimer’s disease is less likely to occur in patients with AF undergoing catheter ablation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/europace/euad109 |
| الإتاحة: | https://doi.org/10.1093/europace/euad109Test https://academic.oup.com/europace/article-pdf/25/5/euad109/50487494/euad109.pdfTest |
| حقوق: | https://creativecommons.org/licenses/by-nc/4.0Test/ |
| رقم الانضمام: | edsbas.F39C43A8 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/europace/euad109 |
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