دورية أكاديمية
The complexity of cancer immunotherapy illustrated through skin tumors.
| العنوان: | The complexity of cancer immunotherapy illustrated through skin tumors. |
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| المؤلفون: | Vieco-Martí, I, López-Carrasco, A, de la Cruz-Merino, L, Noguera, R, Álvaro Naranjo, T |
| سنة النشر: | 2022 |
| المجموعة: | Sistema Sanitario Público de Andalucía (SSPA): Repositorio |
| مصطلحات موضوعية: | Tumor microenvironment, genomics, immune system, metabolism, microbiota, skin tumors, Antigens, Neoplasm, Biomarkers, Tumor, Humans, Immunotherapy, Neoplasms, Skin Neoplasms |
| الوصف: | Skin tumours are among the cancer types most sensitive to immunotherapy, due to their unique immunogenic features including skin-associated lymphoid tissue, high mutational load, overexpression of tumour antigens, and high frequency of viral antigens. Despite this high immunotherapy response rate, however, ultimately most skin tumours develop similar treatment resistance to most other malignant tumours, which highlights the need for in-depth study of mechanisms of response and resistance to immunotherapy. A bibliographic review of the most recent publications regarding currently in use and emerging biomarkers on skin tumors has been done. Predictive biomarkers of treatment response, biomarkers that warn of possible resistance, and emerging markers, the majority of a systemic nature, are described. Including factors affecting not only genomics, but also the immune system, nervous system, microbiota, tumour microenvironment, metabolism and stress. For accurate diagnosis of tumour type, knowledge of its functional mechanisms and selection of a comprehensive therapeutic protocol, this inclusive view of biology, health and disease is fundamental. This field of study could also become a valuable source of practical information applicable to other areas of oncology and immunotherapy. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1724-6008 |
| العلاقة: | http://hdl.handle.net/10668/20217Test; https://doi.org/10.1177/03936155221088884Test |
| DOI: | 10.1177/03936155221088884 |
| الإتاحة: | https://doi.org/10.1177/03936155221088884Test http://hdl.handle.net/10668/20217Test |
| حقوق: | open access |
| رقم الانضمام: | edsbas.F34D46E |
| قاعدة البيانات: | BASE |
| تدمد: | 17246008 |
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| DOI: | 10.1177/03936155221088884 |