دورية أكاديمية
Haemodynamic response to crystalloids or colloids in shock: an exploratory subgroup analysis of a randomised controlled trial
| العنوان: | Haemodynamic response to crystalloids or colloids in shock: an exploratory subgroup analysis of a randomised controlled trial |
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| المؤلفون: | Heming, Nicholas, Elatrous, Souheil, Jaber, Samir, Dumenil, Anne Sylvie, Cousson, Joel, Forceville, Xavier, Kimmoun, Antoine, Trouillet, Jean Louis, Fichet, Jerome, Anguel, Nadia, Darmon, Michael, Martin, Claude, Chevret, Sylvie, Annane, Djillali |
| المساهمون: | Service médical des soins intensifs CHU Raymond Poincaré, Hôpital Raymond Poincaré AP-HP, Infection et inflammation (2I), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Monastir - University of Monastir (UM), Physiologie & médecine expérimentale du Cœur et des Muscles U 1046 (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier), Hôpital Antoine Béclère, Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital universitaire Robert Debré Reims (CHU Reims), Centre Hospitalier de Meaux, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), CHU Pitié-Salpêtrière AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université Pierre et Marie Curie - Paris 6 (UPMC), Centre cardiologique du Nord (CCN), Hôpital Bicêtre AP-HP, Le Kremlin-Bicêtre, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Saint-Louis, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Hôpital Nord CHU - APHM, Service de biostatistiques et information médicale Saint-Louis, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal Paris |
| المصدر: | ISSN: 2044-6055 ; BMJ Open ; https://hal.sorbonne-universite.fr/hal-01700757Test ; BMJ Open, 2017, 7 (10), pp.e016736. ⟨10.1136/bmjopen-2017-016736⟩. |
| بيانات النشر: | HAL CCSD BMJ Publishing Group |
| سنة النشر: | 2017 |
| المجموعة: | Université de Versailles Saint-Quentin-en-Yvelines: HAL-UVSQ |
| مصطلحات موضوعية: | [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| الوصف: | for the CRISTAL Investigators ; International audience ; Objective To compare the haemodynamic effect of crystalloids and colloids during acute severe hypovolaemic shock.Design Exploratory subgroup analysis of a multicentre randomised controlled trial (Colloids Versus Crystalloids for the Resuscitation of the Critically Ill, CRISTAL, ClinicalTrials.gov NCT00318942).Setting CRISTAL was conducted in intensive care units in Europe, North Africa and Canada.Participants Current analysis included all patients who had a pulmonary artery catheter in place at randomisation. 220 patients (117 received crystalloids vs 103 colloids) underwent pulmonary artery catheterisation.Intervention Crystalloids versus colloids for fluid resuscitation in hypovolaemic shock.Outcome measures Haemodynamic data were collected at the time of randomisation and subsequently on days 1, 2, 3, 4, 5, 6 and 7.Results Median cumulative volume of fluid administered during the first 7 days was higher in the crystalloids group than in the colloids group (3500 (2000–6000) vs 2500 (1000–4000) mL, p=0.01). Patients in the colloids arm exhibited a lower heart rate over time compared with those allocated to the crystalloids arm (p=0.014). There was no significant difference in Cardiac Index (p=0.053), mean blood pressure (p=0.4), arterial lactates (p=0.9) or global Sequential Organ Failure Assessment score (p=0.3) over time between arms.Conclusions During acute severe hypovolaemic shock, patients monitored by a pulmonary artery catheter achieved broadly similar haemodynamic outcomes, using lower volumes of colloids than crystalloids. The heart rate was lower in the colloids arm. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-01700757; https://hal.sorbonne-universite.fr/hal-01700757Test; https://hal.sorbonne-universite.fr/hal-01700757/documentTest; https://hal.sorbonne-universite.fr/hal-01700757/file/e016736.full.pdfTest |
| DOI: | 10.1136/bmjopen-2017-016736 |
| الإتاحة: | https://doi.org/10.1136/bmjopen-2017-016736Test https://hal.sorbonne-universite.fr/hal-01700757Test https://hal.sorbonne-universite.fr/hal-01700757/documentTest https://hal.sorbonne-universite.fr/hal-01700757/file/e016736.full.pdfTest |
| حقوق: | http://creativecommons.org/licenses/byTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.F33B1659 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1136/bmjopen-2017-016736 |
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