دورية أكاديمية
The killer immunoglobulin-like receptor KIR3DL1 in combination with HLA-Bw4 is protective against multiple sclerosis in African Americans
| العنوان: | The killer immunoglobulin-like receptor KIR3DL1 in combination with HLA-Bw4 is protective against multiple sclerosis in African Americans |
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| المؤلفون: | Hollenbach, Jill, A, Pando, Marcelo, J, Caillier, Stacy, J, Gourraud, Pierre-Antoine, Oksenberg, Jorge, R |
| المساهمون: | Department of Neurology San Francisco, CA, USA, University of California San Francisco (UC San Francisco), University of California (UC)-University of California (UC), Department of Laboratory Medicine and Pathology Mayo Clinic Rochester, Mayo Clinic Rochester, Centre de Recherche en Transplantation et Immunologie (U1064 Inserm - CRTI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), This study was supported by grants from the National Institute of Health (R01NS046297 and U19NS095774). Recruitment of study participants and sample acquisition was supported by the National Multiple Sclerosis Society (RG2899-D11). |
| المصدر: | ISSN: 1466-4879. |
| بيانات النشر: | HAL CCSD Open Access Hybrid Model Option B |
| سنة النشر: | 2016 |
| المجموعة: | Inserm: HAL (Institut national de la santé et de la recherche médicale) |
| مصطلحات موضوعية: | [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| الوصف: | International audience ; We investigated the role of the KIR loci and their HLA class I ligands in a large cohort of African American MS patients (N=907) and controls (N=1456). No significant differences in carrier frequencies for any KIR locus or haplotype were observed between cases and controls. However, examination of KIR in the context of their cognate HLA ligands revealed a strong protective effect for KIR3DL1 in combination with HLA-A and-B alleles bearing the Bw4 motif (p=10[−8] ; OR=0.60, CI=0.50-0.71) and the Bw4 ligand alone (Table 3; p<10[−6] ; OR=0.63, CI=0.53-0.75). The observed effect cannot be explained by either a specific HLA-B allele or by linkage disequilibrium with HLA-DRB1 or HLA-A. The protective effect was observed only in individuals who were not positive for the MS risk allele HLA-DRB1*15:01 (p<10[−6] ; OR=0.61, CI=0.51-0.74). Our study, the first investigation of KIR and MS in African Americans, confirms and refines previous findings in a European cohort. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/26866467; inserm-02150105; https://inserm.hal.science/inserm-02150105Test; https://inserm.hal.science/inserm-02150105/documentTest; https://inserm.hal.science/inserm-02150105/file/nihms747044.pdfTest; PUBMED: 26866467; PUBMEDCENTRAL: PMC5105680 |
| DOI: | 10.1038/gene.2016.5 |
| الإتاحة: | https://doi.org/10.1038/gene.2016.5Test https://inserm.hal.science/inserm-02150105Test https://inserm.hal.science/inserm-02150105/documentTest https://inserm.hal.science/inserm-02150105/file/nihms747044.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.F2E254C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/gene.2016.5 |
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