دورية أكاديمية
Functional and 123I-MIBG scintigraphy assessment of cardiac adrenergic dysfunction in diabetes
| العنوان: | Functional and 123I-MIBG scintigraphy assessment of cardiac adrenergic dysfunction in diabetes |
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| المؤلفون: | Rasmussen, Thorsten K, Borghammer, Per, Finnerup, Nanna B, Jensen, Troels S, Hansen, John, Knudsen, Karoline, Singer, Wolfgang, Lamotte, Guillaume, Terkelsen, Astrid J |
| المصدر: | Rasmussen , T K , Borghammer , P , Finnerup , N B , Jensen , T S , Hansen , J , Knudsen , K , Singer , W , Lamotte , G & Terkelsen , A J 2024 , ' Functional and 123I-MIBG scintigraphy assessment of cardiac adrenergic dysfunction in diabetes ' , Autonomic Neuroscience: Basic and Clinical , vol. 252 , 103155 . https://doi.org/10.1016/j.autneu.2024.103155Test |
| سنة النشر: | 2024 |
| المجموعة: | Aalborg University (AAU): Publications / Aalborg Universitet: Publikationer |
| مصطلحات موضوعية: | Autonomic nervous system, Autonomic vascular control, Cardiac autonomic regulation, I-metaiodobenzylguanidine (MIBG), Type 2 diabetes |
| الوصف: | Objectives: To assess the agreement between clinical cardiovascular adrenergic function and cardiac adrenergic innervation in type 2 diabetes patients (T2D). Methods: Thirty-three patients with T2D were investigated bimodally through (1) a standardized clinical cardiovascular adrenergic assessment, evaluating adequacy of blood pressure responses to the Valsalva maneuver and (2) 123 I-meta-iodobenzylguanidine (MIBG) scintigraphy assessing myocardial adrenergic innervation measured as early and delayed heart heart/mediastinum (H/M) ratio, and washout rate (WR). Results: T2D patients had significantly lower early and delayed H/M-ratios, and lower WR, compared to laboratory specific reference values. Thirteen patients had an abnormal adrenergic composite autonomic severity score (CASS > 0). Patients with abnormal CASS scores had significantly higher early H/M ratios (1.76 [1.66–1.88] vs. 1.57 [1.49–1.63], p < 0.001), higher delayed H/M ratios (1.64 [1.51:1.73] vs. 1.51 [1.40:1.61] (p = 0.02)), and lower WR (−0.13(0.10) vs −0.05(0.07), p = 0.01). Lower Total Recovery and shorter Pressure Recovery Time responses from the Valsalva maneuver was significantly correlated to lower H/M early (r = 0.55, p = 0.001 and r = 0.5, p = 0.003, respectively) and lower WR for Total Recovery (r = −0.44, p = 0.01). Conclusion: The present study found impairment of sympathetic innervation in T2D patients based on parameters derived from MIBG cardiac scintigraphy (low early H/M, delayed H/M, and WR). These results confirm prior studies. We found a mechanistically inverted relationship with favourable adrenergic cardiovascular responses being significantly associated unfavourable MIBG indices for H/M early and delayed. This paradoxical relationship needs to be further explored but could indicate adrenergic hypersensitivity in cardiac sympathetic denervated T2D patients. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://vbn.aau.dk/da/publications/b2f36ca7-9153-48d8-88c3-3150b5878fccTest |
| DOI: | 10.1016/j.autneu.2024.103155 |
| الإتاحة: | https://doi.org/10.1016/j.autneu.2024.103155Test https://vbn.aau.dk/da/publications/b2f36ca7-9153-48d8-88c3-3150b5878fccTest https://vbn.aau.dk/ws/files/661452714/1-s2.0-S1566070224000092-main.pdfTest http://www.scopus.com/inward/record.url?scp=85185550744&partnerID=8YFLogxKTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.F2D35597 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.autneu.2024.103155 |
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