دورية أكاديمية
Response evaluation in patients with colorectal liver metastases: RECIST version 1.1 versus modified CT criteria
| العنوان: | Response evaluation in patients with colorectal liver metastases: RECIST version 1.1 versus modified CT criteria |
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| المساهمون: | Woo-Suk Chung, Mi-Suk Park, Sang Joon Shin, Song-Ee Baek, Yeo-Eun Kim, Jin Young Choi, Myeong-Jin Kim, Choi, Jin Young, Kim, Myeong Jin, Kim, Yeo Eun, Park, Mi Sook, Baek, Song Ee, Shin, Sang Joon, Chung, Woo Suk, Park, Mi-Suk |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Adult, Aged, Angiogenesis Inhibitors/therapeutic use, Antibodies, Monoclonal, Humanized/therapeutic use, Antineoplastic Combined Chemotherapy Protocols/therapeutic use, Bevacizumab, Colorectal Neoplasms/diagnostic imaging, Colorectal Neoplasms/drug therapy, Colorectal Neoplasms/pathology, Contrast Media, Humans, Image Processing, Computer-Assisted, Iohexol/analogs & derivatives, Liver Neoplasms/diagnostic imaging, Liver Neoplasms/secondary, Male, Middle Aged, Multidetector Computed Tomography, Prognosis, colorectal cancer, liver metastasis, modified CT criteria, RECIST 1.1, Response Evaluation Criteria in Solid Tumors (RECIST), treatment response, tumor density, tumor size |
| الوصف: | OBJECTIVE: Our retrospective study compared Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1 with modified CT criteria to determine their respective utilities as a prognostic indicator. Using both sets of criteria, we compared treatment responses of patients with colorectal liver metastases treated with bevacizumab-containing chemotherapy with those of patients treated with chemotherapy alone. MATERIALS AND METHODS: Fifty-nine patients who received bevacizumab-containing chemotherapy (n=30, group 1) or chemotherapy alone (n=29, group 2) for the treatment of colorectal carcinoma underwent contrast-enhanced CT before treatment and 2 months after treatment. Two radiologists determined changes in tumor size and density between the pretreatment and 2-month follow-up CT images. RECIST 1.1 assesses responses on the basis of changes in tumor size, and the modified CT criteria assesses responses on the basis of changes in tumor density and size. Responses were correlated with time to tumor progression by log rank test. RESULTS: According to RECIST 1.1, nine of 30 patients (30%) in group 1 and 12 of 29 patients (41%) in group 2 were good responders. According to the modified CT criteria, 23 of 30 patients in group 1 (77%) and 23 of 29 patients in group 2 (79%) were good responders. As assessed by the modified CT criteria, good responders in both groups had significantly longer time to tumor progression than poor responders (p<0.05). As assessed by RECIST 1.1, good responders in group 1 had significantly longer time to tumor progression than poor responders (p=0.0154), but there was no difference in group 2. CONCLUSION: Evaluating treatment response with tumor size and density changes on CT was a better predictor of time to tumor progression than changes in tumor size alone in both groups. ; open |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 0361-803X 1546-3141 |
| العلاقة: | AMERICAN JOURNAL OF ROENTGENOLOGY; J00116; OAK-2012-01680; https://ir.ymlib.yonsei.ac.kr/handle/22282913/89450Test; T201203189; AMERICAN JOURNAL OF ROENTGENOLOGY, Vol.199(4) : 809-815, 2012 |
| DOI: | 10.2214/AJR.11.7910 |
| الإتاحة: | https://ir.ymlib.yonsei.ac.kr/handle/22282913/89450Test |
| حقوق: | CC BY-NC-ND 2.0 KR ; https://creativecommons.org/licenses/by-nc-nd/2.0/krTest/ |
| رقم الانضمام: | edsbas.F28F40A9 |
| قاعدة البيانات: | BASE |
| تدمد: | 0361803X 15463141 |
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| DOI: | 10.2214/AJR.11.7910 |