دورية أكاديمية
Methodology for the nocturnal cardiac arrhythmia ancillary study of the ADVENT-HF trial in patients with heart failure with reduced ejection fraction and sleep-disordered breathing
| العنوان: | Methodology for the nocturnal cardiac arrhythmia ancillary study of the ADVENT-HF trial in patients with heart failure with reduced ejection fraction and sleep-disordered breathing |
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| المؤلفون: | Horvath, CM, Fisser, C, Bradley, TD, Floras, JS, Sossalla, S, Parati, G, Zeman, F, Castiglioni, Paolo, Faini, A, Rankin, F, Arzt, M |
| المساهمون: | Horvath, Cm, Fisser, C, Bradley, Td, Floras, J, Sossalla, S, Parati, G, Zeman, F, Castiglioni, Paolo, Faini, A, Rankin, F, Arzt, M |
| سنة النشر: | 2022 |
| المجموعة: | IRInSubria - Institutional Repository Insubria (Università degli Studi dell’Insubria) |
| مصطلحات موضوعية: | Heart failure, Premature ventricular complex, Premature atrial complex, Sleep-disordered breathing, Inter-observer reliability, Method, ADVENT-HF |
| الوصف: | Background: Sleep disordered breathing (SDB) may trigger nocturnal cardiac arrhythmias (NCA) in patients with heart failure with reduced ejection fraction (HFrEF). The NCA ancillary study of the ADVENT-HF trial will test whether, in HFrEF-patients with SDB, peak-flow-triggered adaptive servo-ventilation (ASVpf) reduces NCA. To this end, accurate scoring of NCA from polysomnography (PSG) is required.Objective: To develop a method to detect NCA accurately from a single-lead electrocardiogram (ECG) recorded during PSG and assess inter-observer agreement for NCA detection.Methods: Quality assurance of ECG analysis included training of the investigators, development of standardized technical quality, guideline-conforming semi-automated NCA-scoring via Holter-ECG software and imple-mentation of an arrhythmia adjudication committee. To assess inter-observer agreement, the ECG was analysed by two independent investigators and compared for agreement on premature ventricular complexes (PVC) /h, premature atrial complexes/h (PAC) as well as for other NCA in 62 patients from two centers of the ADVENT-HF trial.Results: The intraclass correlation coefficients for PVC/h and PAC/h were excellent: 0.99 (95%-confidence in-terval [CI]: 0.99-0.99) and 0.99 (95%-CI: 0.97-0.99), respectively. No clinically relevant difference in inter-observer classification of other NCA was found. The detection of non-sustained ventricular tachycardia (18% versus 19%) and atrial fibrillation (10% versus 11%) was similar between the two investigators. No sustained ventricular tachycardia was detected. Conclusion: These findings indicate that our methods are very reliable for scoring NCAs and are adequate to apply for the entire PSG data set of the ADVENT-HF trial. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/35615735; info:eu-repo/semantics/altIdentifier/wos/WOS:000812275100009; volume:41; firstpage:1; lastpage:10; numberofpages:10; journal:INTERNATIONAL JOURNAL OF CARDIOLOGY. HEART & VASCULATURE; https://hdl.handle.net/11383/2146053Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85134035720 |
| DOI: | 10.1016/j.ijcha.2022.101057 |
| الإتاحة: | https://doi.org/10.1016/j.ijcha.2022.101057Test https://hdl.handle.net/11383/2146053Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.F262098E |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.ijcha.2022.101057 |
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