دورية أكاديمية
Association of Salpingectomy With Delayed Oophorectomy Versus Salpingo-oophorectomy With Quality of Life in BRCA1/2 Pathogenic Variant Carriers:A Nonrandomized Controlled Trial
| العنوان: | Association of Salpingectomy With Delayed Oophorectomy Versus Salpingo-oophorectomy With Quality of Life in BRCA1/2 Pathogenic Variant Carriers:A Nonrandomized Controlled Trial |
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| المؤلفون: | Steenbeek, Miranda P, Harmsen, Marline G, Hoogerbrugge, Nicoline, de Jong, Marieke Arts, Maas, Angela H E M, Prins, Judith B, Bulten, Johan, Teerenstra, Steven, van Bommel, Majke H D, van Doorn, Helena C, Mourits, Marian J E, van Beurden, Marc, Zweemer, Ronald P, Gaarenstroom, Katja N, Slangen, Brigitte F M, Brood-van Zanten, Monique M A, Vos, M Caroline, Piek, Jurgen M J, van Lonkhuijzen, Luc R C W, Apperloo, Mirjam J A, Coppus, Sjors F P J, Massuger, Leon F A G, IntHout, Joanna, Hermens, Rosella P M G, de Hullu, Joanne A |
| المصدر: | Steenbeek , M P , Harmsen , M G , Hoogerbrugge , N , de Jong , M A , Maas , A H E M , Prins , J B , Bulten , J , Teerenstra , S , van Bommel , M H D , van Doorn , H C , Mourits , M J E , van Beurden , M , Zweemer , R P , Gaarenstroom , K N , Slangen , B F M , Brood-van Zanten , M M A , Vos , M C , Piek , J M J , van .... |
| سنة النشر: | 2021 |
| الوصف: | Importance: Most women with a BRCA1/2 pathogenic variant undergo premature menopause with potential short- and long-term morbidity due to the current method of ovarian carcinoma prevention: risk-reducing salpingo-oophorectomy (RRSO). Because the fallopian tubes play a key role in ovarian cancer pathogenesis, salpingectomy with delayed oophorectomy may be a novel risk-reducing strategy with benefits of delaying menopause. Objective: To compare menopause-related quality of life after risk-reducing salpingectomy (RRS) with delayed oophorectomy with RRSO in carriers of the BRCA1/2 pathogenic variant. Design, Setting, and Participants: A multicenter nonrandomized controlled preference trial (TUBA study), with patient recruitment between January 16, 2015, and November 7, 2019, and follow-up at 3 and 12 months after surgery was conducted in all Dutch university hospitals and a few large general hospitals. In the Netherlands, RRSO is predominantly performed in these hospitals. Patients at the clinical genetics or gynecology department between the ages of 25 and 40 years (BRCA1) or 25 to 45 years (BRCA2) who were premenopausal, had completed childbearing, and were undergoing no current treatment for cancer were eligible. Interventions: Risk-reducing salpingo-oophorectomy at currently recommended age or RRS after completed childbearing with delayed oophorectomy. After RRSO was performed, hormone replacement therapy was recommended for women without contraindications. Main Outcomes and Measures: Menopause-related quality of life as assessed by the Greene Climacteric Scale, with a higher scale sum (range, 0-63) representing more climacteric symptoms. Secondary outcomes were health-related quality of life, sexual functioning and distress, cancer worry, decisional regret, and surgical outcomes. Results: A total of 577 women (mean [SD] age, 37.2 [3.5] years) were enrolled: 297 (51.5%) were pathogenic BRCA1 variant carriers and 280 (48.5%) were BRCA2 pathogenic variant carriers. At the time of analysis, 394 patients had ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://research.vumc.nl/en/publications/18584e54-1f67-47ac-b63f-6a0cff8e02d3Test |
| DOI: | 10.1001/jamaoncol.2021.1590 |
| الإتاحة: | https://doi.org/10.1001/jamaoncol.2021.1590Test https://research.vumc.nl/en/publications/18584e54-1f67-47ac-b63f-6a0cff8e02d3Test http://www.scopus.com/inward/record.url?scp=85108056560&partnerID=8YFLogxKTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.F2388EB6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1001/jamaoncol.2021.1590 |
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