رسالة جامعية
Organic Phases In Microfluidic Systems: Enabling Real-Time Sensing of Small Molecules
| العنوان: | Organic Phases In Microfluidic Systems: Enabling Real-Time Sensing of Small Molecules |
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| المؤلفون: | Quevedo, Shannon |
| المساهمون: | Bailey, Ryan Castle, Kim, Jinsang, Chen, Zhan, Meyerhoff, Mark E, Shultz, Ginger Victoria |
| سنة النشر: | 2021 |
| المجموعة: | University of Michigan: Deep Blue |
| مصطلحات موضوعية: | Organic Extractions, Microfluidics, Polymer Brushes, Microring Resonators, Microfluidic Droptodes, Chemistry, Science |
| الوصف: | Small molecules play an important role in a variety of industrial and pharmaceutical processes. Many small molecules have important biological side effects, ranging from impacting blood pressure regulation to cancer. As such, it is important to be able to monitor the concentration of these molecules in both environmental and biological conditions. However, small molecule monitoring is challenging due to the low concentration, the low signal and the lack of specificity traditionally associated with small molecule detection. This thesis explores enhancing small molecule sensing by using organic phases in microfluidic systems, allowing pre-concentration of molecules and additional selectivity. Chapter 1 explores the current detection methods used for small molecules, focusing on those that use organic phases for separative procedures. Organic phase separative procedures are divided into two categories: solid phase or liquid-liquid extraction. Advancements in separative technology, including molecularly imprinted polymers, nanoparticles, and dispersive liquid-liquid microextraction are explored. Separative/detection platforms are then explored, including methods based on stimuli responsive polymers, ion-selective optodes and microfluidic droptodes. When using organic phases for separative procedures, there is a need to characterize the interactions between the analyte and the organic phase. Chapter 2 demonstrates the novel use of silicon photonic microring resonators to characterize in situ polymer brush-small molecule interactions. By monitoring resonant wavelength shifts, brush-solvent-analyte interaction parameters, including partition and diffusion coefficients and pKas, can be extracted from a single set of data or from successive analyte introductions using a single brush-coated sensor. of polymer brushes with solvents and analytes, not easily accessed by other techniques. Droplet microfluidic optodes, or “droptodes”, have also recently emerged as a powerful technology for rapid detection of small ions in ... |
| نوع الوثيقة: | thesis |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://hdl.handle.net/2027.42/170047Test; https://dx.doi.org/10.7302/3092Test; orcid:0000-0003-0614-9212; Wetzler, Shannon; 0000-0003-0614-9212 |
| DOI: | 10.7302/3092 |
| الإتاحة: | https://doi.org/10.7302/3092Test https://hdl.handle.net/2027.42/170047Test |
| رقم الانضمام: | edsbas.F1A11D1E |
| قاعدة البيانات: | BASE |
| DOI: | 10.7302/3092 |
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