دورية أكاديمية
miR-106b is a novel target to promote muscle regeneration and restore satellite stem cell function in injured Duchenne dystrophic muscle
| العنوان: | miR-106b is a novel target to promote muscle regeneration and restore satellite stem cell function in injured Duchenne dystrophic muscle |
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| المؤلفون: | Lara Rodriguez-Outeiriño, Francisco Hernandez-Torres, Felicitas Ramirez de Acuña, Alberto Rastrojo, Carlota Creus, Alejandra Carvajal, Luis Salmeron, Marisol Montolio, Patricia Soblechero-Martin, Virginia Arechavala-Gomeza, Diego Franco, Amelia Eva Aranega |
| المصدر: | Molecular Therapy: Nucleic Acids, Vol 29, Iss , Pp 769-786 (2022) |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2022 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | MT: Non-coding RNAs, satellite cell, miR-106b, stemness, muscle regeneration, muscular dystrophy, Therapeutics. Pharmacology, RM1-950 |
| الوصف: | Satellite cells (SCs), muscle stem cells, display functional heterogeneity, and dramatic changes linked to their regenerative capabilities are associated with muscle-wasting diseases. SC behavior is related to endogenous expression of the myogenic transcription factor MYF5 and the propensity to enter into the cell cycle. Here, we report a role for miR-106b reinforcing MYF5 inhibition and blocking cell proliferation in a subset of highly quiescent SC population. miR-106b down-regulation occurs during SC activation and is required for proper muscle repair. In addition, miR-106b is increased in dystrophic mice, and intramuscular injection of antimiR in injured mdx mice enhances muscle regeneration promoting transcriptional changes involved in skeletal muscle differentiation. miR-106b inhibition promotes the engraftment of human muscle stem cells. Furthermore, miR-106b is also high in human dystrophic muscle stem cells and its inhibition improves intrinsic proliferative defects and increases their myogenic potential. This study demonstrates that miR-106b is an important modulator of SC quiescence, and that miR-106b may be a new target to develop therapeutic strategies to promote muscle regeneration improving the regenerative capabilities of injured dystrophic muscle. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2162-2531 |
| العلاقة: | http://www.sciencedirect.com/science/article/pii/S2162253122002244Test; https://doaj.org/toc/2162-2531Test; https://doaj.org/article/e03b3b8ff3f848cdb79d4103a8b2c6f8Test |
| DOI: | 10.1016/j.omtn.2022.08.025 |
| الإتاحة: | https://doi.org/10.1016/j.omtn.2022.08.025Test https://doaj.org/article/e03b3b8ff3f848cdb79d4103a8b2c6f8Test |
| رقم الانضمام: | edsbas.F0FE931 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 21622531 |
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| DOI: | 10.1016/j.omtn.2022.08.025 |