دورية أكاديمية
DNA methylation from germline cells in veterans with PTSD
| العنوان: | DNA methylation from germline cells in veterans with PTSD |
|---|---|
| المؤلفون: | Mehta, Divya, Pelzer, Elise, Bruenig, Dagmar, Lawford, Bruce, McLeay, Sarah, Morris, Phillip, Gibson, John, Young, Ross, Voisey, Joanne, Harvey, Wendy, Romaniuk, Madeline, Crawford, Darrell, Colquhoun, David, Dwyer, Miriam, O'Sullivan, Robyn, Cooksley, Graham, Strakosch, Christopher, Thomson, Rachel |
| المصدر: | Journal of Psychiatric Research |
| بيانات النشر: | Elsevier Ltd. |
| سنة النشر: | 2019 |
| المجموعة: | Queensland University of Technology: QUT ePrints |
| الوصف: | In this study we investigated genome-wide sperm DNA methylation patterns in trauma-exposed Vietnam veterans. At the genome-wide level, we identified 3 CpG sites associated with PTSD in sperm including two intergenic and one CpG within the CCDC88C gene. Of those associated with PTSD in sperm at a nominal level, 1868 CpGs were also associated with PTSD in peripheral blood (5.6% overlap) including the RORA, CRHR1 and DOCK2 genes that have been previously implicated in PTSD. A total of 10 CpG sites were significantly associated with a reported history of a diagnosed mental health condition in children and reached genome-wide significance. CpGs associated with a history of a reported mental health condition in children were also enriched (90% of tested genes) for genes previously reported to be resistant to demethylation, making them strong candidates for transgenerational inheritance. In conclusion, our findings identify a unique sperm-specific DNA methylation pattern that is associated with PTSD. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| العلاقة: | https://eprints.qut.edu.au/197166/1/134692.pdfTest; Mehta, Divya, Pelzer, Elise, Bruenig, Dagmar, Lawford, Bruce, McLeay, Sarah, Morris, Phillip, Gibson, John, Young, Ross, Voisey, Joanne, Harvey, Wendy, Romaniuk, Madeline, Crawford, Darrell, Colquhoun, David, Dwyer, Miriam, O'Sullivan, Robyn, Cooksley, Graham, Strakosch, Christopher, & Thomson, Rachel (2019) DNA methylation from germline cells in veterans with PTSD. Journal of Psychiatric Research, 116, pp. 42-50.; https://eprints.qut.edu.au/197166Test/; Faculty of Health; Institute of Health and Biomedical Innovation; School of Psychology & Counselling |
| الإتاحة: | https://doi.org/10.1016/j.jpsychires.2019.06.001Test https://eprints.qut.edu.au/197166Test/ |
| حقوق: | free_to_read ; http://creativecommons.org/licenses/by-nc-nd/2.5Test/ ; Consult author(s) regarding copyright matters ; This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au |
| رقم الانضمام: | edsbas.F0F22328 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |