دورية أكاديمية
冠心病患者经皮冠状动脉介入治疗术后抗血小板药物治疗监测及平均血小板体积变化 ; Monitoring of antiplatelet therapy and changes of mean platelet volume after percutaneous coronary intervention in the patients with coronary heart disease
| العنوان: | 冠心病患者经皮冠状动脉介入治疗术后抗血小板药物治疗监测及平均血小板体积变化 ; Monitoring of antiplatelet therapy and changes of mean platelet volume after percutaneous coronary intervention in the patients with coronary heart disease |
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| المؤلفون: | 苗林子, 陆遥, 屈晨雪, 龚岩, 由然, 关杰, 龚艳君 |
| المساهمون: | 北京大学第一医院检验科,北京,100034, 北京大学第一医院心内科,北京,100034 |
| المصدر: | CSCD ; 万方 ; 知网 ; http://d.g.wanfangdata.com.cn/Periodical_lcjyzz201706012.aspxTest |
| بيانات النشر: | 临床检验杂志 |
| سنة النشر: | 2017 |
| المجموعة: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| مصطلحات موضوعية: | 平均血小板体积, 血栓弹力图, 光学比浊法, 经皮冠状动脉介入治疗, 抗血小板, 氯吡格雷抵抗, 阿司匹林抵抗, mean platelet volume, thrombelastography, light transmittance aggregometry, percutaneous coronary intervention, antiplatelet drug, clopidogrel hyporesponsiveness, aspirin hyporesponsiveness |
| الوصف: | 目的 比较血栓弹力图(TEG)和光学比浊法(LTA)在监测冠心病患者经皮冠状动脉介入治疗(PCI)术后抗血小板药物中的相关性;观察PCI术后双联抗血小板治疗患者平均血小板体积(MPV)变化.方法 回顾2013年3月至2014年5月在北京大学第一医院行PCI并接受规范双联抗血小板治疗的患者177例;回顾分析其TEG测定的二磷酸腺苷(ADP)、花生四烯酸(AA)诱导的血小板抑制率,服用抗血小板药物前后MPV,以及其中99例患者LTA测定的血小板聚集率.结果 ADP、ARA诱导的LTA血小板聚集率与TEG血小板抑制率无相关性(P均＞0.05).氯吡格雷低反应性LTA和TEG检出率分别为30.3％和45.5％,阿司匹林低反应性检出率分别为19.2％和31.3％,低反应性检出率LTA低于TEG法(P＜0.05).177例患者中,氯吡格雷低反应组和敏感组、阿司匹林低反应性组和敏感组服药后MPV均较服药前降低(P均＜0.01);服药前及服药后氯吡格雷低反应性组MPV均低于敏感组(P均＜0.05);氯吡格雷及阿司匹林低反应组服药后PLT高于服药前(P均＜0.05).结论 TEG和LTA两种方法相关性较差,抗血小板药物低反应检出率均较高,值得临床医生注意;服用双联抗血小板药物后MPV降低;服药后PLT上升患者更易发生药物低反应性;MPV偏低患者氯吡格雷低反应性发生可能性更大. ; Objective To compare the consistency of thrombelastography (TEG) and light transmittance aggregometry (LTA) in monitoring the antiplatelet therapy of the patients with coronary heart disease (CHD) after percutaneous coronary intervention (PCI),and observe the changes of mean platelet volume (MPV) of the patients treated with aspirin and clopidogrel after PCI.Methods A total of 177 patients undergoing PCI and the treatment of aspirin and clopidogrel in Peking University First Hospital during March 2014 and May 2015 were enrolled in the study.Their adenosine diphosphate (ADP) or arachidonic acid (AA) induced platelet inhibition rates determined by TEG,MPV before and after antiplatelet therapy,and the maximum platelet aggregation rates measured by LTA from 99 patients were retrospectively analyzed.Results There was no any correlation between the maximum aggregation rates measured by LTA and the platelet inhibition rates determined by TEG regardless of using ADP or AA as agonist (all P ＞ 0.05).The detection rates of clopidogrel hyporesponsiveness determined by LTA and TEG were 30.3％ and 45.5％,respectively,while those of aspirin hyporesponsiveness were 19.2％ and 31.3％,respectively.The detection rate of hyporesponsiveness determined by LTA was significant lower than that by TEG (P ＜ 0.05).The MPVs after antiplatelet therapy were significant lower than that before treatment (all P ＜ 0.01) regardless of clopidogrel hyporesponsive or ... |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | English |
| تدمد: | 1001-764X |
| العلاقة: | 临床检验杂志. 2017, 35(6), 439-443.; 1899378; http://hdl.handle.net/20.500.11897/465772Test |
| DOI: | 10.13602/j.cnki.jcls.2017.06.12 |
| الإتاحة: | https://doi.org/20.500.11897/465772Test https://doi.org/10.13602/j.cnki.jcls.2017.06.12Test https://hdl.handle.net/20.500.11897/465772Test |
| رقم الانضمام: | edsbas.F0EFA417 |
| قاعدة البيانات: | BASE |
| تدمد: | 1001764X |
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| DOI: | 10.13602/j.cnki.jcls.2017.06.12 |