دورية أكاديمية
P0594USEFULNESS OF THE NEUTROPHIL-TO-LYMPHOCYTE AND PLATELET-TO-LYMPHOCYTE RATIOS IN THE COMMUNITY-ADQUIRED ACUTE KIDNEY INJURY
| العنوان: | P0594USEFULNESS OF THE NEUTROPHIL-TO-LYMPHOCYTE AND PLATELET-TO-LYMPHOCYTE RATIOS IN THE COMMUNITY-ADQUIRED ACUTE KIDNEY INJURY |
|---|---|
| المؤلفون: | Peña Porta, Jose Maria, Castellano Calvo, Almudena, Coscojuela Otto, Ana, Tomás latorre, Alejandro, Ferreras Gascó, José Antonio, Martín Azara, Pilar, Alvarez Lipe, Rafael |
| المصدر: | Nephrology Dialysis Transplantation ; volume 35, issue Supplement_3 ; ISSN 0931-0509 1460-2385 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Transplantation, Nephrology |
| الوصف: | Introduction and Aims The neutrophil-to-lymphocyte (NLR) and platelet-to-lymphocyte (PLR) ratios have been identified as markers of inflammation and endothelial dysfunction in recent literature. Both are easily measured, reproducible and inexpensive, therefore cost-effective. To date, its usefulness as prognostic markers in community-acquired acute kidney injury (CA-AKI) has not been evaluated. The aim of this study was to analyze the usefulness of the NLR and PLR in terms of morbidity and mortality in community-acquired acute kidney injury. Method We established a cohort of 308 patients with community-acquired acute kidney injury (CA-AKI) admitted to the Nephrology service of a third level hospital from January 2010 to February 2015. NLR and PLR ratios were obtained with the levels of the first analysis performed at admission. Results We studied 308 patients with CA-AKI, 180 were men (58,4 %), mean age was 73.22 (±13,95). The mean length of stay was 12,25 days (±11,69). The etiology of CA-AKI was divided in prerenal 214 cases (69.5%); renal 71 cases (23.1%); obstructive 23 cases (7,5%). AKI KDIGO stages were stage I, 45 cases (14.6%); stage II, 34 cases (11%); stage III 229 cases (74.4%). Previous chronic kidney disease (CKD) was detected in 212 cases (68.8%). A total of 54 patients (17,15%) required hemodialysis and 38 patients died during admission (12.3%). Mean NLR was 9.14 ± 8,47 (95% IC 8,2-10,1). Mean PLR was 236,99 ± 228,41 (95% IC 211,38-262,6). NLR according to etiology was: prerenal 8,55±6,8; renal 9,37±9,8; obstructive 13,99±14,82 (significant differences of the latter group compared to the prerenal group). PLR according to etiology: prerenal 228,31±216,34; renal 236,15±233,77; obstructive 320,37±304,89 (non-significant differences). Within the group of prerenal origin, 79 cases were complicated by the development of acute tubular necrosis (ATN). These cases presented a higher NLR (NLR of ATN 10,7±10,28 vs NLR of pure prerenal 7,8±5,6; p=0,026). There were no significant differences between ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/ndt/gfaa142.p0594 |
| الإتاحة: | https://doi.org/10.1093/ndt/gfaa142.p0594Test http://academic.oup.com/ndt/article-pdf/35/Supplement_3/gfaa142.P0594/33359893/gfaa142.p0594.pdfTest |
| حقوق: | https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_modelTest |
| رقم الانضمام: | edsbas.F09E6938 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/ndt/gfaa142.p0594 |
|---|