دورية أكاديمية
Antagonizing the alpha(4)beta(1) Integrin, but Not alpha(4)beta(7), Inhibits Leukocytic Infiltration of the Central Nervous System in Rhesus Monkey Experimental Autoimmune Encephalomyelitis
| العنوان: | Antagonizing the alpha(4)beta(1) Integrin, but Not alpha(4)beta(7), Inhibits Leukocytic Infiltration of the Central Nervous System in Rhesus Monkey Experimental Autoimmune Encephalomyelitis |
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| المؤلفون: | Haanstra, Krista G., Hofman, Sam O., Estevao, Dave M. Lopes, Blezer, Erwin L. A., Bauer, Jan, Yang, Li-Li, Wyant, Tim, Csizmadia, Vilmos, 't Hart, Bert A., Fedyk, Eric R. |
| المصدر: | Haanstra , K G , Hofman , S O , Estevao , D M L , Blezer , E L A , Bauer , J , Yang , L-L , Wyant , T , Csizmadia , V , 't Hart , B A & Fedyk , E R 2013 , ' Antagonizing the alpha(4)beta(1) Integrin, but Not alpha(4)beta(7), Inhibits Leukocytic Infiltration of the Central Nervous System in Rhesus Monkey Experimental Autoimmune Encephalomyelitis ' , Journal of Immunology , vol. 190 , no. 5 , pp. 1961-1973 . https://doi.org/10.4049/jimmunol.1202490Test |
| سنة النشر: | 2013 |
| المجموعة: | University of Groningen research database |
| مصطلحات موضوعية: | PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY, EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS, MYELIN OLIGODENDROCYTE GLYCOPROTEIN, ACTIVE CROHNS-DISEASE, RELAPSING MULTIPLE-SCLEROSIS, CELL-ADHESION MOLECULE-1, PLACEBO-CONTROLLED TRIAL, NONHUMAN PRIMATE MODELS, BLOOD-BRAIN-BARRIER, MEMORY T-CELLS |
| الوصف: | The immune system is characterized by the preferential migration of lymphocytes through specific tissues (i.e., tissue tropism). Tissue tropism is mediated, in part, by the alpha(4) integrins expressed by T lymphocytes. The alpha(4)beta(1) integrin mediates migration of memory T lymphocytes into the CNS, whereas the alpha(4)beta(7) integrin mediates migration preferentially into gastrointestinal tissue. This paradigm was established primarily from investigations in rodents; thus, the objective of this investigation was to determine if blocking the alpha(4)beta(7) integrin exclusively would affect migration of T lymphocytes into the CNS of primates. The effects of the dual alpha(4)beta(1) and alpha(4)beta(7) antagonist natalizumab were compared with those of the alpha(4)beta(7) antagonist vedolizumab on experimental autoimmune encephalomyelitis in the rhesus monkey. Animals received an initial i.v. bolus of placebo, natalizumab (30 mg/kg), or vedolizumab (30 mg/kg) before intracutaneous immunization with recombinant human myelin oligodendrocyte glycoprotein and then Ab once weekly thereafter. Natalizumab prevented CNS inflammation and demyelination significantly (p <0.05), compared with time-matched placebo control animals, whereas vedolizumab did not inhibit these effects, despite saturating the alpha(4)beta(7) integrin in each animal for the duration of the investigation. These results demonstrate that blocking alpha(4)beta(7) exclusively does not inhibit immune surveillance of the CNS in primates. The Journal of Immunology, 2013, 190: 1961-1973. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://research.rug.nl/en/publications/c02caf9c-c7d7-4b85-80cc-496c537c2dd1Test |
| DOI: | 10.4049/jimmunol.1202490 |
| الإتاحة: | https://doi.org/10.4049/jimmunol.1202490Test https://hdl.handle.net/11370/c02caf9c-c7d7-4b85-80cc-496c537c2dd1Test https://research.rug.nl/en/publications/c02caf9c-c7d7-4b85-80cc-496c537c2dd1Test https://pure.rug.nl/ws/files/231639510/1961.full.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.F0872C9C |
| قاعدة البيانات: | BASE |
| DOI: | 10.4049/jimmunol.1202490 |
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