التفاصيل البيبلوغرافية
| العنوان: |
Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment. |
| المؤلفون: |
Schulte-Schrepping, Jonas, Reusch, Nico, De Domenico, Elena, Landthaler, Markus, Li, Yang, Ludwig, Kerstin, Makarewicz, Oliwia, Marz, Manja, McHardy, Alice, Mertes, Christian, Nöthen, Markus, Nürnberg, Peter, Ohler, Uwe, Wendisch, Daniel, Ossowski, Stephan, Overmann, Jörg, Peter, Silke, Pfeffer, Klaus, Poetsch, Anna R, Pühler, Alfred, Rajewsky, Nikolaus, Ralser, Markus, Rieß, Olaf, Ripke, Stephan, Grasshoff, Martin, Nunes da Rocha, Ulisses, Rosenstiel, Philip, Saliba, Antoine-Emmanuel, Sander, Leif Erik, Sawitzki, Birgit, Schiffer, Philipp, Schulte, Eva-Christina, Sczyrba, Alexander, Stegle, Oliver, Stoye, Jens, Kapellos, Theodore S, Theis, Fabian, Vehreschild, Janne, Vogel, Jörg, von Kleist, Max, Walker, Andreas, Walter, Jörn, Wieczorek, Dagmar, Ziebuhr, John, Beckstette, Michael, Pecht, Tal, Saglam, Adem, Dietrich, Oliver, Mei, Henrik E, Schulz, Axel R, Paclik, Daniela, Conrad, Claudia, Kunkel, Désirée, Vafadarnejad, Ehsan, Xu, Cheng-Jian, Horne, Arik, Herbert, Miriam, Drews, Anna, Thibeault, Charlotte, Pfeiffer, Moritz, Hippenstiel, Stefan, Baßler, Kevin, Hocke, Andreas, Müller-Redetzky, Holger, Heim, Katrin-Moira, Machleidt, Felix, Uhrig, Alexander, Bosquillon de Jarcy, Laure, Jürgens, Linda, Stegemann, Miriam, Glösenkamp, Christoph R, Volk, Hans-Dieter, Schlickeiser, Stephan, Goffinet, Christine, Wyler, Emanuel, Georg, Philipp, Schneider, Maria, Dang-Heine, Chantip, Neuwinger, Nick, Kappert, Kai, Tauber, Rudolf, Corman, Victor, Zhang, Bowen, Raabe, Jan, Kaiser, Kim Melanie, Vinh, Michael To, Rieke, Gereon, Meisel, Christian, Ulas, Thomas, Becker, Matthias, Geffers, Robert, Witzenrath, Martin, Drosten, Christian, Krämer, Benjamin, Suttorp, Norbert, von Kalle, Christof, Kurth, Florian, Händler, Kristian, Schultze, Joachim L, Aschenbrenner, Anna C, Nattermann, Jacob, Krammer, Tobias, Initiative, Deutsche COVID-19 OMICS, Angelov, Angel, Bals, Robert, Bartholomäus, Alexander, Becker, Anke, Bezdan, Daniela, Bonifacio, Ezio, Bork, Peer, Clavel, Thomas, Brumhard, Sophia, Colome-Tatche, Maria, Diefenbach, Andreas, Dilthey, Alexander, Fischer, Nicole, Förstner, Konrad, Frick, Julia-Stefanie, Gagneur, Julien, Goesmann, Alexander, Hain, Torsten, Hummel, Michael, Bonaguro, Lorenzo, Janssen, Stefan, Kalinowski, Jörn, Kallies, René, Kehr, Birte, Keller, Andreas, Kim-Hellmuth, Sarah, Klein, Christoph, Kohlbacher, Oliver, Korbel, Jan O, Kurth, Ingo |
| المصدر: |
Cell 182(6), 1419 - 1440.e23 (2020). doi:10.1016/j.cell.2020.08.001 |
| بيانات النشر: |
Elsevier |
| سنة النشر: |
2020 |
| مصطلحات موضوعية: |
info:eu-repo/classification/ddc/610, Adult, Aged, CD11 Antigens: genetics, CD11 Antigens: metabolism, COVID-19, Cells, Cultured, Coronavirus Infections: blood, Coronavirus Infections: immunology, Coronavirus Infections: pathology, Female, HLA-DR Antigens: genetics, HLA-DR Antigens: metabolism, Humans, Male, Middle Aged, Myeloid Cells: cytology, Myeloid Cells: immunology, Myelopoiesis, Pandemics, Pneumonia, Viral: blood, Viral: immunology, Viral: pathology, Proteome: genetics, Proteome: metabolism, Proteomics, Single-Cell Analysis, SARS-CoV-2 |
| جغرافية الموضوع: |
DE |
| الوصف: |
Coronavirus disease 2019 (COVID-19) is a mild to moderate respiratory tract infection, however, a subset of patients progress to severe disease and respiratory failure. The mechanism of protective immunity in mild forms and the pathogenesis of severe COVID-19 associated with increased neutrophil counts and dysregulated immune responses remain unclear. In a dual-center, two-cohort study, we combined single-cell RNA-sequencing and single-cell proteomics of whole-blood and peripheral-blood mononuclear cells to determine changes in immune cell composition and activation in mild versus severe COVID-19 (242 samples from 109 individuals) over time. HLA-DRhiCD11chi inflammatory monocytes with an interferon-stimulated gene signature were elevated in mild COVID-19. Severe COVID-19 was marked by occurrence of neutrophil precursors, as evidence of emergency myelopoiesis, dysfunctional mature neutrophils, and HLA-DRlo monocytes. Our study provides detailed insights into the systemic immune response to SARS-CoV-2 infection and reveals profound alterations in the myeloid cell compartment associated with severe COVID-19. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| العلاقة: |
info:eu-repo/semantics/altIdentifier/issn/0092-8674; info:eu-repo/semantics/altIdentifier/pmid/pmid:32810438; info:eu-repo/semantics/altIdentifier/issn/1097-4172; https://pub.dzne.de/record/154366Test; https://pub.dzne.de/search?p=id:%22DZNE-2021-00219%22Test |
| الإتاحة: |
https://doi.org/10.1016/j.cell.2020.08.001Test
https://pub.dzne.de/record/154366Test
https://pub.dzne.de/search?p=id:%22DZNE-2021-00219%22Test |
| حقوق: |
info:eu-repo/semantics/closedAccess |
| رقم الانضمام: |
edsbas.F03DADBF |
| قاعدة البيانات: |
BASE |
