التفاصيل البيبلوغرافية
| العنوان: |
Response‐guided therapy in patients with genotype 1 hepatitis C virus: Current status and future prospects |
| المؤلفون: |
Lawitz, Eric J, Membreno, Fernando E |
| المساهمون: |
Boehringer Ingelheim Pharmaceuticals, Inc. |
| المصدر: |
Journal of Gastroenterology and Hepatology ; volume 29, issue 8, page 1574-1581 ; ISSN 0815-9319 1440-1746 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2014 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
On‐treatment responses to antiviral therapy are used to determine duration of therapy in patients being treated for genotype 1 hepatitis C virus infection. Such use of response‐guided therapy has successfully reduced exposure of patients to the side‐effects of pegylated interferon and ribavirin without jeopardizing overall treatment success. Response‐guided therapy is an integral part of treatment using the current standard treatments involving the direct‐acting antiviral ( DAA ) agents—boceprevir or telaprevir—combined with pegylated interferon/ribavirin. Improvements in our understanding of the kinetics of viral load during antiviral therapy have shown us that more potent suppression of viral replication increases the rate of viral eradication, providing impetus for the development of more potent DAA s. Emerging results from clinical trials of these agents—including trials of interferon‐free DAA combinations—suggest that very high rates of viral eradication are achievable, even in patients who failed to respond to previous courses of interferon‐based therapy. Furthermore, because of these high rates of treatment success, on‐treatment assessment of viral response may become unnecessary. The field of hepatitis C virus therapy is evolving rapidly and current trends indicate that the era of simple treatment regimens with high rates of success and good tolerability are near. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1111/jgh.12632 |
| الإتاحة: |
https://doi.org/10.1111/jgh.12632Test |
| حقوق: |
http://onlinelibrary.wiley.com/termsAndConditions#vorTest |
| رقم الانضمام: |
edsbas.F03396BC |
| قاعدة البيانات: |
BASE |
