كتاب
Interactome of obesity: Obesidome: Genetic obesity, stress induced obesity, pathogenic obesity interaction
| العنوان: | Interactome of obesity: Obesidome: Genetic obesity, stress induced obesity, pathogenic obesity interaction |
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| المؤلفون: | Geronikolou S.A., Pavlopoulou A., Cokkinos D., Chrousos G. |
| المصدر: | Advances in Experimental Medicine and Biology ; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85030665430&doi=10.1007%2f978-3-319-57379-3_21&partnerID=40&md5=814d737660cda759a204d60cdb836849Test |
| سنة النشر: | 2017 |
| المجموعة: | University of Thessaly Institutional Repository / Ιδρυματικό Αποθετήριο Πανεπιστημίου Θεσσαλίας |
| مصطلحات موضوعية: | agouti related protein, amine oxidase (flavin containing) isoenzyme A, angiotensinogen, argipressin, catechol methyltransferase, cholecystokinin, cholinesterase, cocaine and amphetamine regulated transcript peptide, corticotropin releasing factor, dipeptidyl carboxypeptidase, gamma interferon, ghrelin, ghrelin receptor, glucagon, histamine methyltransferase, insulin, intercellular adhesion molecule 1, interleukin 6, interleukin 6 receptor, Janus kinase 2, leptin, leptin receptor, melanocortin 1 receptor, melanocortin 2 receptor, melanocortin 3 receptor, melanocortin 4 receptor, melanocortin 5 receptor, protein fos, somatomedin C, unindexed drug |
| الوصف: | Obesity is a chronic disease of increasing prevalence reaching epidemic proportions. Genetic defects as well as epigenetic effects contribute to the obesity phenotype. Investigating gene (e.g. MC4R defects)-environment (behavior, infectious agents, stress) interactions is a relative new field of great research interest. In this study, we have made an effort to create an interactome (henceforth referred to as “obesidome”), where extrinsic stressors response, intrinsic predisposition, immunity response to inflammation and autonomous nervous system implications are integrated. These pathways are presented in one interactome network for the first time. In our study, obesity-related genes/gene products were found to form a complex interactions network. © Springer International Publishing AG 2017. |
| نوع الوثيقة: | book part |
| اللغة: | English |
| تدمد: | 00652598 |
| العلاقة: | http://hdl.handle.net/11615/72248Test |
| DOI: | 10.1007/978-3-319-57379-3_21 |
| الإتاحة: | https://doi.org/10.1007/978-3-319-57379-3_21Test http://hdl.handle.net/11615/72248Test |
| رقم الانضمام: | edsbas.F002F394 |
| قاعدة البيانات: | BASE |
| تدمد: | 00652598 |
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| DOI: | 10.1007/978-3-319-57379-3_21 |