دورية أكاديمية
Inhibition of apoptosis by gamma interferon in cells and mice infected with Chlamydia muridarum (the mouse pneumonitis strain of Chlamydia trachomatis)
| العنوان: | Inhibition of apoptosis by gamma interferon in cells and mice infected with Chlamydia muridarum (the mouse pneumonitis strain of Chlamydia trachomatis) |
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| المؤلفون: | Perfettini, Jean-Luc, Darville, Toni, Dautry-Varsat, Alice, Rank, Roger G., Ojcius, David M. |
| المصدر: | All Dugoni School of Dentistry Faculty Articles |
| بيانات النشر: | Scholarly Commons |
| سنة النشر: | 2002 |
| المجموعة: | University of the Pacific, McGeorge School of Law: Scholarly Commons |
| مصطلحات موضوعية: | Biochemistry, Biophysics, and Structural Biology, Immunity, Immunology of Infectious Disease, Life Sciences, Medical Immunology, Medicine and Health Sciences |
| الوصف: | The effect of gamma interferon (IFN-γ) on apoptosis due to infection by Chlamydia muridarum (the mouse pneumonitis strain of Chlamydia trachomatis) was studied in epithelial cells in culture and in the genital tracts of mice. IFN-γ concentrations that induce the formation of aberrant, persistent chlamydiae inhibit apoptosis due to C. muridarum infection. In cells treated with an IFN-γ concentration that leads to the development of a heterogenous population of normal and aberrant Chlamydia vacuoles, apoptosis was inhibited preferentially in cells that contained the aberrant vacuoles. The inhibitory effect of IFN-γ appears to be due in part to expression of host cell indoleamine 2,3-dioxygenase activity, since inhibition of apoptosis could be partially reversed through coincubation with exogenous tryptophan. Apoptotic cells were observed in the genital tracts of wild-type mice infected with C. muridarum, and a significantly larger number of apoptotic cells was detected in infected IFN-γ-deficient mice. These results suggest that IFN-γ may contribute to pathogenesis of persistent Chlamydia infections in vivo by preventing apoptosis of infected cells. |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| العلاقة: | https://scholarlycommons.pacific.edu/dugoni-facarticles/147Test; https://scholarlycommons.pacific.edu/context/dugoni-facarticles/article/1146/viewcontent/Infect._20Immun._2002_Perfettini_2559_65.pdfTest |
| DOI: | 10.1128/IAI.70.5.2559-2565.2002 |
| الإتاحة: | https://doi.org/10.1128/IAI.70.5.2559-2565.2002Test https://scholarlycommons.pacific.edu/dugoni-facarticles/147Test https://scholarlycommons.pacific.edu/context/dugoni-facarticles/article/1146/viewcontent/Infect._20Immun._2002_Perfettini_2559_65.pdfTest |
| رقم الانضمام: | edsbas.EF9089F1 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1128/IAI.70.5.2559-2565.2002 |
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