رسالة جامعية
Preparation and characterisation of composite nanomaterials for radionuclide delivery ; Priprava i karakterizacija kompozitnih nanomaterijala za dostavu radionuklida
| العنوان: | Preparation and characterisation of composite nanomaterials for radionuclide delivery ; Priprava i karakterizacija kompozitnih nanomaterijala za dostavu radionuklida |
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| المؤلفون: | Pantalon Juraj, Natalija |
| المساهمون: | Steinberg, Ivana |
| بيانات النشر: | Sveučilište u Zagrebu. Fakultet kemijskog inženjerstva i tehnologije. University of Zagreb. Faculty of Chemical Engineering and Technology. |
| سنة النشر: | 2016 |
| المجموعة: | Croatian Digital Theses Repository (National and University Library in Zagreb) |
| مصطلحات موضوعية: | nanocomposites, hydroxyapatite, TiO2, phosphonic acids, 99mTc, 223Ra, nanokompoziti, hidroksiapatit, fosfonske kiseline, PRIRODNE ZNANOSTI. Kemija. Primijenjena kemija, NATURAL SCIENCES. Chemistry. Applied Chemistry |
| الوصف: | The aim of this thesis was to prepare composite nanomaterials for targeted delivery of radionuclides used for cancer diagnosis and therapy. Hydroxyapatite and TiO2 nanoparticles were used as vehicles for targeted delivery because of their suitable properties such as biocompatibility and radiochemical stability. Nanocomposites were prepared by precipitating phosphonate ligands or polyethylene glycol with nanoparticles. The role of the phosphonates is binding of radionuclides and stabilisation of nanoparticles. Prepared nanocomposites were labelled with 99mTc, a gamma emmiter used in tumor imaging and 223Ra, an alpha emmiter used in targeted alpha therapy. Phosphonic acids ethylenediamine tetra(methylenephosphonic) acid, propylenediamine tetra(methylenephosphonic) acid and 1,2-cyclohexyldiamine tetra(methylenephosphonic) acid were purified by ion exchange chromatography and used for preparation of nanocomposites. Besides mentioned ligands, methylene diphosphonic acid, etidronic acid, zoledronic acid, pamidronic acid and polyethylene glycol were used for experiments. For labelling with 99mTc, the best yields were obtained for 99mTc-CDTMP-HAp (89%), and 99mTc-PDTMP-HAp (93%) stabilised before labelling and 99mTc-MDP-HAp (92%) and 99mTc-HEDP-HAp (89%) stabilised during their preparation. TiO2 nanocomposites all had yields >93%. Nanocomposites 223Ra-zoledronic acid-HAp stabilised after labelling showed the best yields (60%) for labelling with 223Ra. ; Cilj ovog rada bio je priprema kompozitnih nanomaterijala za ciljanu dostavu radionuklida koji se koriste u dijagnostici i terapiji raka. Nanočestice hidroksiapatita i TiO2 korištene su kao nosači za ciljanu dostavu zbog njihovih pogodnih svojstava, kao što su biokompatibilnost i radiokemijska stabilnost. Nanokompoziti su pripravljeni miješanjem fosfonatnih liganda ili polietilen glikola s nanočesticama. Uloga fosfonata je vezanje radionuklida i stabilizacija nanočestica. Pripremljeni nanokompoziti obilježeni su s 99mTc, radionuklidom koji emitira gama zračenje i ... |
| نوع الوثيقة: | master thesis |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://zir.nsk.hr/islandora/object/fkit:281Test; https://urn.nsk.hr/urn:nbn:hr:149:023711Test; https://repozitorij.unizg.hr/islandora/object/fkit:281Test; https://repozitorij.unizg.hr/islandora/object/fkit:281/datastream/PDFTest |
| الإتاحة: | https://zir.nsk.hr/islandora/object/fkit:281Test https://urn.nsk.hr/urn:nbn:hr:149:023711Test https://repozitorij.unizg.hr/islandora/object/fkit:281Test https://repozitorij.unizg.hr/islandora/object/fkit:281/datastream/PDFTest |
| حقوق: | http://rightsstatements.org/vocab/InC/1.0Test/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.EF88541B |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |