التفاصيل البيبلوغرافية
| العنوان: |
LXR agonist improves peripheral neuropathy and modifies PNS immune cells in aged mice |
| المؤلفون: |
Gavini, Chaitanya K, Elshareif, Nadia, Aubert, Gregory, Germanwala, Anand V, Calcutt, Nigel A, Mansuy-Aubert, Virginie |
| المصدر: |
Journal of Neuroinflammation, vol 19, iss 1 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2022 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Biomedical and Clinical Sciences, Neurosciences, Clinical Sciences, Chronic Pain, Pain Research, Aging, Nutrition, Peripheral Neuropathy, Neurodegenerative, 5.1 Pharmaceuticals, 2.1 Biological and endogenous factors, Development of treatments and therapeutic interventions, Aetiology, Animals, Ganglia, Spinal, Hyperalgesia, Liver X Receptors, Mice, Peripheral Nervous System Diseases, Sciatic Nerve, GW3965, Immunology, Neurology & Neurosurgery |
| الوصف: |
BackgroundPeripheral neuropathy is a common and progressive disorder in the elderly that interferes with daily activities. It is of importance to find efficient treatments to treat or delay this age-related neurodegeneration. Silencing macrophages by reducing foamy macrophages showed significant improvement of age-related degenerative changes in peripheral nerves of aged mice. We previously demonstrated that activation of the cholesterol sensor Liver X receptor (LXR) with the potent agonist, GW3965, alleviates pain in a diet-induced obesity model. We sought to test whether LXR activation may improve neuropathy in aged mice.Methods21-month-old mice were treated with GW3965 (25mg/Kg body weight) for 3months while testing for mechanical allodynia and thermal hyperalgesia. At termination, flow cytometry was used to profile dorsal root ganglia and sciatic nerve cells. Immune cells were sorted and analyzed for cholesterol and gene expression. Nerve fibers of the skin from the paws were analyzed. Some human sural nerves were also evaluated. Comparisons were made using either t test or one-way ANOVA.ResultsTreatment with GW3965 prevented the development of mechanical hypersensitivity and thermal hyperalgesia over time in aged mice. We also observed change in polarization and cholesterol content of sciatic nerve macrophages accompanied by a significant increase in nerve fibers of the skin.ConclusionsThese results suggest that activation of the LXR may delay the PNS aging by modifying nerve-immune cell lipid content. Our study provides new potential targets to treat or delay neuropathy during aging. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt5187r3h3; https://escholarship.org/uc/item/5187r3h3Test |
| الإتاحة: |
https://escholarship.org/uc/item/5187r3h3Test |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.EF08C72D |
| قاعدة البيانات: |
BASE |
