دورية أكاديمية
Consequences of negative energy balance on follicular development and oocyte quality in primiparous sows
| العنوان: | Consequences of negative energy balance on follicular development and oocyte quality in primiparous sows |
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| المؤلفون: | Costermans, N.G.J., Teerds, K.J., Middelkoop, Anouschka, Roelen, B.A.J., Schoevers, E.J., van Tol, H.T.A., Laurenssen, B.F.A., Koopmanschap, R.E., Zhao, Yu, Blokland, Marco, van Tricht, E.F., Zak, L.J., Keijer, J., Kemp, B., Soede, N.M. |
| المصدر: | Biology of Reproduction 102 (2020) 2 ; ISSN: 0006-3363 |
| سنة النشر: | 2020 |
| المجموعة: | Wageningen UR (University & Research Centre): Digital Library |
| مصطلحات موضوعية: | estradiol, follicle, follicular development, gonadal steroids, in vitro fertilization (IVF), in vitro maturation (IVM), insulin-like growth factor, lactation, metabolism, porcine, zygote |
| الوصف: | Metabolic demands of modern hybrid sows have increased over the years, which increases the chance that sows enter a substantial negative energy balance (NEB) during lactation. This NEB can influence the development of follicles and oocytes that will give rise to the next litter. To study effects of a lactational NEB on follicular development, we used 36 primiparous sows of which 18 were subjected to feed restriction (3.25 kg/day) and 18 were full-fed (6.5 kg/day) during the last 2 weeks of a 24.1 ± 0.3 day lactation. Feed restriction resulted in a 70% larger lactational body weight loss and 76% higher longissimus dorsi depth loss, but similar amounts of backfat loss compared to the full fed sows. These changes were accompanied by lower plasma insulin-like growth factor 1 (IGF1) and higher plasma creatinine levels in the restricted sows from the last week of lactation onward. Ovaries were collected 48 h after weaning. Restricted sows had a lower average size of the 15 largest follicles (−26%) and cumulus–oocyte complexes showed less expansion after 22 h in vitro maturation (−26%). Less zygotes of restricted sows reached the metaphase stage 24 h after in vitro fertilization and showed a higher incidence of polyspermy (+89%). This shows that feed restriction had severe consequences on oocyte developmental competence. Follicular fluid of restricted sows had lower IGF1 (−56%) and steroid levels (e.g., β-estradiol, progestins, and androgens), which indicated that follicles of restricted sows were less competent to produce steroids and growth factors needed for oocytes to obtain full developmental competence. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text/html |
| اللغة: | English |
| العلاقة: | https://edepot.wur.nl/511251Test; https://research.wur.nl/en/publications/consequences-of-negative-energy-balance-on-follicular-developmentTest |
| DOI: | 10.1093/biolre/ioz175 |
| الإتاحة: | https://doi.org/10.1093/biolre/ioz175Test https://research.wur.nl/en/publications/consequences-of-negative-energy-balance-on-follicular-developmentTest |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test/ ; Wageningen University & Research |
| رقم الانضمام: | edsbas.EF07E90C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/biolre/ioz175 |
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