دورية أكاديمية
A “Slide Rule” to Adjust Insulin Dose Using Trend Arrows in Adults with Type 1 Diabetes: Test in Silico and in Real Life
| العنوان: | A “Slide Rule” to Adjust Insulin Dose Using Trend Arrows in Adults with Type 1 Diabetes: Test in Silico and in Real Life |
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| المؤلفون: | Bruttomesso D., Boscari F., Lepore G., Noaro G., Cappon G., Girelli A., Bozzetto L., Tumminia A., Grassi G., Sparacino G., Laviola L., Facchinetti A. |
| المساهمون: | Bruttomesso, D., Boscari, F., Lepore, G., Noaro, G., Cappon, G., Girelli, A., Bozzetto, L., Tumminia, A., Grassi, G., Sparacino, G., Laviola, L., Facchinetti, A. |
| سنة النشر: | 2021 |
| المجموعة: | IRIS Università degli Studi di Napoli Federico II |
| مصطلحات موضوعية: | Continuous glucose monitoring, Insulin dose adjustment, Slide rule, Trend arrow, Type 1 diabetes |
| الوصف: | Introduction: In persons with type 1 diabetes (T1D) insulin dosing can be adjusted based on trend arrows derived from continuous glucose monitoring (CGM). We propose a slide rule with narrower blood glucose intervals and more classes of insulin sensitivity than are available in current models. Methods: The slide rule was tested in silico, in which a meal was simulated in 100 virtual subjects and the insulin bolus was calculated either in the standard way based on the insulin-to-carbohydrate ratio and the correction factor or according to the slide rule, following which the percentage time spent in range (70–180 mg/dl; %TIR), hypoglycemia (< 70 mg/dl; %THYPO), and hyperglycemia (> 180 mg/dl; %THYPER) was compared between the methods during the 4 h after the meal. Slide rule performance was also tested in real life by analyzing the same variables at during the 4 h postprandial period in 27 individuals with T1D. Only meals starting while the rate of change was at least 1 mg/dl per minute (increasing or decreasing) were considered for analysis. Results: In silico, when the preprandial trend arrow was increasing, our slide rule reduced %THYPER and increased %TIR (p < 0.05), whereas when the preprandial trend arrow was decreasing, it reduced %THYPO and slightly increased %THYPER (p < 0.05). In real life, our slide rule kept subjects on target for 70.8 and 91.6% of postprandial time when preprandial trend arrows were increasing or decreasing, respectively. Conclusion: The proposed slide rule performed well both in silico and in real life, suggesting that it could be safely adopted by individuals with T1D to improve glucose control. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/wos/WOS:000629551200001; volume:12; issue:5; firstpage:1313; lastpage:1324; numberofpages:12; journal:DIABETES THERAPY; http://hdl.handle.net/11588/869743Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85102853507 |
| DOI: | 10.1007/s13300-021-01020-2 |
| الإتاحة: | https://doi.org/10.1007/s13300-021-01020-2Test http://hdl.handle.net/11588/869743Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.EEB9D4EC |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s13300-021-01020-2 |
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