دورية أكاديمية
Polymer-free sirolimus-eluting stent use in Europe and Asia: Ethnic differences in demographics and clinical outcomes.
| العنوان: | Polymer-free sirolimus-eluting stent use in Europe and Asia: Ethnic differences in demographics and clinical outcomes. |
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| المؤلفون: | Florian Krackhardt, Matthias Waliszewski, Wan Azman Wan Ahmad, Viktor Kočka, Petr Toušek, Bronislav Janek, Milan Trenčan, Peter Krajči, Fernando Lozano, Koldobika Garcia-San Roman, Imanol Otaegui Irurueta, Bruno Garcia Del Blanco, Lucie Wachowiak, Victoria Vilalta Del Olmo, Eduard Fernandez Nofrerías, Myung Ho Jeong, Byung-Chun Jung, Kyu-Rock Han, Christophe Piot, Laurent Sebagh, Jérôme Rischner, Michel Pansieri, Matthias Leschke, Tae Hoon Ahn |
| المصدر: | PLoS ONE, Vol 15, Iss 1, p e0226606 (2020) |
| بيانات النشر: | Public Library of Science (PLoS) |
| سنة النشر: | 2020 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Background The objective of this study was to assess regional and ethnic differences in an unselected patient population treated with polymer-free sirolimus-eluting stents (PF-SES) in Asia and Europe. Methods Two all-comers observational studies based on the same protocol (ClinicalTrials.gov Identifiers: NCT02629575 and NCT02905214) were combined for data analysis to assure sufficient statistical power. The primary endpoint was the accumulated target lesion revascularization (TLR) rate at 9-12 months. Results Of the total population of 7243 patients, 44.0% (3186) were recruited in the Mediterranean region and 32.0% (2317) in central Europe. The most prominent Asian region was South Korea (17.6%, 1274) followed by Malaysia (5.7%, 413). Major cardiovascular risk factors varied significantly across regions. The overall rates for accumulated TLR and MACE were low with 2.2% (140/6374) and 4.4% (279/6374), respectively. In ACS patients, there were no differences in terms of MACE, TLR, MI and accumulated mortality between the investigated regions. Moreover, dual antiplatelet therapy (DAPT) regimens were substantially longer in Asian countries even in patients with stable coronary artery disease as compared to those in Europe. Conclusions PF-SES angioplasty is associated with low clinical event rates in all regions. Further reductions in clinical event rates seem to be associated with longer DAPT regimens. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1932-6203 |
| العلاقة: | https://doi.org/10.1371/journal.pone.0226606Test; https://doaj.org/toc/1932-6203Test; https://doaj.org/article/7dad4a5329ea4ad0a22d63cbd997dd3dTest |
| DOI: | 10.1371/journal.pone.0226606 |
| الإتاحة: | https://doi.org/10.1371/journal.pone.0226606Test https://doaj.org/article/7dad4a5329ea4ad0a22d63cbd997dd3dTest |
| رقم الانضمام: | edsbas.EEAA4CC3 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0226606 |