دورية أكاديمية
Somatostatin interneurons in the prefrontal cortex control affective state discrimination in mice
| العنوان: | Somatostatin interneurons in the prefrontal cortex control affective state discrimination in mice |
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| المؤلفون: | Scheggia D., Manago F., Maltese F., Bruni S., Nigro M., Dautan D., Latuske P., Contarini G., Gomez-Gonzalo M., Requie L. M., Ferretti V., Castellani G., Mauro D., Bonavia A., Carmignoto G., Yizhar O., Papaleo F. |
| المساهمون: | Scheggia, D., Manago, F., Maltese, F., Bruni, S., Nigro, M., Dautan, D., Latuske, P., Contarini, G., Gomez-Gonzalo, M., Requie, L. M., Ferretti, V., Castellani, G., Mauro, D., Bonavia, A., Carmignoto, G., Yizhar, O., Papaleo, F. |
| بيانات النشر: | Nature Research 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA |
| سنة النشر: | 2020 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| مصطلحات موضوعية: | Affect, Animal, Interneuron, Male, Mice, Prefrontal Cortex, Somatostatin, Social Behavior |
| الوصف: | The prefrontal cortex (PFC) is implicated in processing of the affective state of others through non-verbal communication. This social cognitive function is thought to rely on an intact cortical neuronal excitatory and inhibitory balance. Here combining in vivo electrophysiology with a behavioral task for affective state discrimination in mice, we show a differential activation of medial PFC (mPFC) neurons during social exploration that depends on the affective state of the conspecific. Optogenetic manipulations revealed a double dissociation between the role of interneurons in social cognition. Specifically, inhibition of mPFC somatostatin (SOM+), but not of parvalbumin (PV+) interneurons, abolishes affective state discrimination. Accordingly, synchronized activation of mPFC SOM+ interneurons selectively induces social discrimination. As visualized by in vivo single-cell microendoscopic Ca2+ imaging, an increased synchronous activity of mPFC SOM+ interneurons, guiding inhibition of pyramidal neurons, is associated with affective state discrimination. Our findings provide new insights into the neurobiological mechanisms of affective state discrimination. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/31844317; info:eu-repo/semantics/altIdentifier/wos/WOS:000507601600006; volume:23; issue:1; firstpage:47; lastpage:60; numberofpages:14; journal:NATURE NEUROSCIENCE; https://hdl.handle.net/11573/1415989Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85076929984 |
| DOI: | 10.1038/s41593-019-0551-8 |
| الإتاحة: | https://doi.org/10.1038/s41593-019-0551-8Test https://hdl.handle.net/11573/1415989Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.ED775197 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41593-019-0551-8 |
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