التفاصيل البيبلوغرافية
| العنوان: |
Recent advances of fluorescent biosensors based on cyclic signal amplification technology in biomedical detection |
| المؤلفون: |
Qu, Hongke, Fan, Chunmei, Chen, Mingjian, Zhang, Xiangyan, Yan, Qijia, Wang, Yumin, Zhang, Shanshan, Gong, Zhaojian, Shi, Lei, Li, Xiayu, Liao, Qianjin, Xiang, Bo, Zhou, Ming, Guo, Can, Li, Guiyuan, Zeng, Zhaoyang, Wu, Xu, Xiong, Wei |
| المساهمون: |
National Natural Science Foundation of China, Overseas Expertise Introduction Project for Discipline Innovation, Natural Science Foundation of Hunan Province, the Fundamental Research Funds for the Central Universities of Central South University |
| المصدر: |
Journal of Nanobiotechnology ; volume 19, issue 1 ; ISSN 1477-3155 |
| بيانات النشر: |
Springer Science and Business Media LLC |
| سنة النشر: |
2021 |
| مصطلحات موضوعية: |
Pharmaceutical Science, Applied Microbiology and Biotechnology, Biomedical Engineering, Molecular Medicine, Medicine (miscellaneous), Bioengineering |
| الوصف: |
The cyclic signal amplification technology has been widely applied for the ultrasensitive detection of many important biomolecules, such as nucleic acids, proteins, enzymes, adenosine triphosphate (ATP), metal ions, exosome, etc. Due to their low content in the complex biological samples, traditional detection methods are insufficient to satisfy the requirements for monitoring those biomolecules. Therefore, effective and sensitive biosensors based on cyclic signal amplification technology are of great significance for the quick and simple diagnosis and treatment of diseases. Fluorescent biosensor based on cyclic signal amplification technology has become a research hotspot due to its simple operation, low cost, short time, high sensitivity and high specificity. This paper introduces several cyclic amplification methods, such as rolling circle amplification (RCA), strand displacement reactions (SDR) and enzyme-assisted amplification (EAA), and summarizes the research progress of using this technology in the detection of different biomolecules in recent years, in order to provide help for the research of more efficient and sensitive detection methods. Graphical Abstract |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1186/s12951-021-01149-z |
| DOI: |
10.1186/s12951-021-01149-z.pdf |
| DOI: |
10.1186/s12951-021-01149-z/fulltext.html |
| الإتاحة: |
https://doi.org/10.1186/s12951-021-01149-zTest |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: |
edsbas.ED2CC052 |
| قاعدة البيانات: |
BASE |
