التفاصيل البيبلوغرافية
| العنوان: |
Weight loss surgery decreases platelet activation in morbidly obese patients |
| المؤلفون: |
Dobrydneva, Yuliya, Periasamy, Monica, Galkina, Elena, Kuhn, Norine, Lieb, David, Fontana, Mark, Wohlgemuth, Stephen, Nadler, Jerry |
| المصدر: |
The FASEB Journal ; volume 26, issue S1 ; ISSN 0892-6638 1530-6860 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2012 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
Bariatric surgery is the most effective treatment to alleviate morbid obesity and its comorbidities, such as type 2 diabetes. Platelets are crucial for the development of thrombosis that often accompanies obesity and diabetes. Hypothesis: bariatric surgery attenuates platelet activation therefore decreasing thrombosis risk. Objective: to determine the effect of bariatric surgery on platelet function in morbidly obese diabetics and non‐diabetics, and compare two types of surgery, Roux‐en‐Y Gastric Bypass (RY) and Lap Banding (LB). Prothrombotic platelet‐monocyte aggregates (PMA) and P‐selectin/PAC‐1 expression on platelets were evaluated pre‐and post‐surgically in whole blood by flow cytometry. In morbidly obese patients, PMA are drastically elevated compared to non‐obese controls. Bariatric surgery decreased platelet activation in all patients. PMA levels (baseline and ADP‐stimulated) decreased early at 1 month after surgery. More significant decrease was in diabetics and after RY. P‐selectin/PAC‐1 expression in ADP‐stimulated blood decreased later at 3 months after surgery. There is no correlation between weight loss and decreased platelet activation after RY, but they do correlate after LB. Therefore gastric bypass appears to be more rapid and efficacious than gastric banding in reducing platelet hyperactivity and alleviating thrombosis risk associated with morbid obesity. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1096/fasebj.26.1_supplement.876.2 |
| الإتاحة: |
https://doi.org/10.1096/fasebj.26.1_supplement.876.2Test |
| حقوق: |
http://onlinelibrary.wiley.com/termsAndConditions#vorTest |
| رقم الانضمام: |
edsbas.ED034F4C |
| قاعدة البيانات: |
BASE |
