دورية أكاديمية
Early mortality in EURODIAB population-based cohorts of type 1 diabetes diagnosed in childhood since 1989
| العنوان: | Early mortality in EURODIAB population-based cohorts of type 1 diabetes diagnosed in childhood since 1989 |
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| المؤلفون: | Patterson, C C, Dahlquist, G, Harjutsalo, V, Joner, G, Feltbower, R G, Svensson, J, Schober, E, Gyürüs, E, Castell, C, Urbonaité, B, Rosenbauer, J, Iotova, V, Thorsson, A V, Soltész, G |
| المساهمون: | Department of Epidemiology and Public Health, Queen's University Belfast, Belfast, UK. c.patterson@qub.ac.uk |
| بيانات النشر: | Springer Verlag |
| سنة النشر: | 2010 |
| المجموعة: | Hirsla - Landspítali University Hospital research archive |
| مصطلحات موضوعية: | Adolescent, Adult, Age of Onset, Cause of Death, Child, Preschool, Cohort Studies, Diabetes Mellitus, Type 1, Europe, Female, Follow-Up Studies, Infant, Newborn, Male, Registries |
| الوصف: | To access publisher full text version of this article. Please click on the hyperlink in Additional Links field ; AIMS/HYPOTHESIS: The aims of this study were to provide a contemporary picture of mortality and causes of death in Europe following a diagnosis of type 1 diabetes made before the 15th birthday, and to examine excess mortality by country for possible links to incidence level or national prosperity. METHODS: Thirteen population-based EURODIAB registers in 12 countries followed-up 28,887 children diagnosed since 1989, either by record linkage to population registers or through contact with doctors providing care. RESULTS: There were 141 deaths in the cohort during 219,061 person-years of follow-up compared with 69.1 deaths expected from national mortality rates, a standardised mortality ratio (SMR) of 2.0 (95% CI 1.7-2.4). The SMR varied from 0 to 4.7 between countries, but showed little relationship with the country's incidence rate or gross domestic product (US$ per capita). The SMR did not change significantly with attained age, calendar period or time since diagnosis. The female SMR (2.7; 95% CI 2.0-3.5) was greater than the male SMR (1.8; 95% CI 1.4-2.2), although absolute numbers of excess deaths were similar in the two sexes. One-third of deaths were classified as directly attributable to diabetes (many with mention of ketoacidosis) and half were unrelated to diabetes. There was a non-significant excess of accidental/violent deaths (48 observed vs 40.7 expected; SMR 1.2; 95% CI 0.9-1.6) but little excess in suicides (11 observed, 10.2 expected; SMR 1.1; 95% CI 0.5-1.9). CONCLUSIONS/INTERPRETATION: Before the onset of late complications, significant excess mortality existed following the diagnosis of type 1 diabetes in childhood, even in recent years. Variation between countries in this excess could not be explained. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0012-186X |
| العلاقة: | http://dx.doi.org/10.1007/s00125-007-0824-8Test; Diabetologia. 2007, 50(12):2439-42; http://hdl.handle.net/2336/104665Test; Diabetologia |
| DOI: | 10.1007/s00125-007-0824-8 |
| الإتاحة: | https://doi.org/10.1007/s00125-007-0824-8Test http://hdl.handle.net/2336/104665Test |
| رقم الانضمام: | edsbas.EBF5626A |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 0012186X |
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| DOI: | 10.1007/s00125-007-0824-8 |