التفاصيل البيبلوغرافية
| العنوان: |
Imbalance of Interleukin-18 and Interleukin-18 Binding Protein in Children with Henoch-Schönlein Purpura |
| المؤلفون: |
Wang, YB, Shan, NN, Chen, O, Gao, Y, Zou, X, Wei, DE, Wang, CX, Zhang, Y |
| المصدر: |
Journal of International Medical Research ; volume 39, issue 6, page 2201-2208 ; ISSN 0300-0605 1473-2300 |
| بيانات النشر: |
SAGE Publications |
| سنة النشر: |
2011 |
| الوصف: |
The balance between interleukin-18 (IL-18) and its endogenous antagonist, IL-18 binding protein (IL-18BP), was evaluated in children with Henoch-Schönlein purpura (HSP). Plasma IL-18 and IL-18BP levels and peripheral blood mononuclear cell IL-18 mRNA expression were significantly higher in patients with active HSP ( n = 30) than in healthy controls ( n = 20); IL-18BP mRNA expression was similar in active HSP and controls. Plasma levels and mRNA expression of IL-18 and IL-18BP in patients in remission ( n = 19) were similar to those in controls. The ratios of IL-18 / IL-18BP plasma levels and IL-18 / IL-18BP mRNA levels in active HSP were significantly higher than in patients in remission and healthy controls. Thus, adequate IL-18BP to block the proinflammatory activity of IL-18 may not be present in active HSP and regulation of the IL-18 / IL-18BP balance might provide a potential therapeutic strategy. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1177/147323001103900616 |
| الإتاحة: |
https://doi.org/10.1177/147323001103900616Test |
| حقوق: |
http://journals.sagepub.com/page/policies/text-and-data-mining-licenseTest |
| رقم الانضمام: |
edsbas.EBA21369 |
| قاعدة البيانات: |
BASE |
