كتاب
From stem cell to unique neuron: combinatorial codes, feedforward loops and target-derived signals – an outlook from the Drosophila apterous neurons
| العنوان: | From stem cell to unique neuron: combinatorial codes, feedforward loops and target-derived signals – an outlook from the Drosophila apterous neurons |
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| المؤلفون: | Thor, S, Stratmann, J |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2017 |
| المجموعة: | The University of Queensland: UQ eSpace |
| مصطلحات موضوعية: | Combinatorial codes, Context-dependency, Feedforward loops, Gene regulation, Genetic cascades, Nervous system development, Neuronal sub-type specification, Target-derived signals, Terminal differentiation, Terminal selector, 2700 Medicine |
| الوصف: | The mammalian nervous system contains vast numbers of neurons of many different sub-types. Understanding neuronal sub-type specification thus continues to be one of the major challenges of modern neurobiology. In addition, different neuronal sub-types are also generated in precise but sometimes vastly different numbers. This underscores the importance of proliferation control during nervous system development. Here, we review progress in understanding cell specification and proliferation control of one particular group of neurons in an invertebrate model system; the Apterous neurons of the Drosophila melanogaster ventral nerve cord. These studies reveal the presence of highly complex genetic pathways involving a multitude of regulatory features such as cell-cell interactions, spatial and temporal cues, terminal selectors, feedforward loops, combinatorial coding and retrograde instructive signals, the integration of which allows for the precise generation of unique neuronal subtypes. |
| نوع الوثيقة: | book part |
| اللغة: | English |
| العلاقة: | orcid:0000-0001-5095-541X |
| الإتاحة: | https://doi.org/10.1016/B978-0-12-809324-5.02415-9Test https://espace.library.uq.edu.au/view/UQ:b1bcf52Test |
| رقم الانضمام: | edsbas.EBA1ECB9 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |