دورية أكاديمية
Proteomic analysis of the human hippocampus identifies neuronal pentraxin 1 (NPTX1) as synapto-axonal target in late-stage Parkinson's disease
| العنوان: | Proteomic analysis of the human hippocampus identifies neuronal pentraxin 1 (NPTX1) as synapto-axonal target in late-stage Parkinson's disease |
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| المؤلفون: | Warth Perez Arias, C., Silbern, I., Gomes, L., Wartmann, H., Dambeck, V., Fanz, J., Neuenroth, L., Baehr, M., Outeiro, T., Bonn, S., Stadelmann-Nessler, C., Rizzoli, S., Lenz, C., Urlaub, H., Lingor, P. |
| المصدر: | Journal of Neurochemistry |
| سنة النشر: | 2023 |
| المجموعة: | Max Planck Society: MPG.PuRe |
| الوصف: | Parkinson's disease (PD) affects a significant proportion of the population over the age of 60 years, and its prevalence is increasing. While symptomatic treatment is available for motor symptoms of PD, non-motor complications such as dementia result in diminished life quality for patients and are far more difficult to treat. In this study, we analyzed PD-associated alterations in the hippocampus of PD patients, since this brain region is strongly affected by PD dementia. We focused on synapses, analyzing the proteome of post-mortal hippocampal tissue from 16 PD cases and 14 control subjects by mass spectrometry. Whole tissue lysates and synaptosomal fractions were analyzed in parallel. Differential analysis combined with bioinformatic network analyses identified neuronal pentraxin 1 (NPTX1) to be significantly dysregulated in PD and interacting with proteins of the synaptic compartment. Modulation of NPTX1 protein levels in primary hippocampal neuron cultures validated its role in synapse morphology. Our analysis suggests that NPTX1 contributes to synaptic pathology in late-stage PD and represents a putative target for novel therapeutic strategies. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | http://hdl.handle.net/21.11116/0000-000D-BE9E-CTest; http://hdl.handle.net/21.11116/0000-000D-BEA0-8Test |
| الإتاحة: | https://doi.org/10.1111/jnc.15924Test http://hdl.handle.net/21.11116/0000-000D-BE9E-CTest http://hdl.handle.net/21.11116/0000-000D-BEA0-8Test |
| حقوق: | info:eu-repo/semantics/openAccess ; https://creativecommons.org/licenses/by-nc/4.0Test/ |
| رقم الانضمام: | edsbas.EB516E22 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |