دورية أكاديمية
Early weight measures and long-term neuropsychological outcome of critically ill neonates and infants:a secondary analysis of the PEPaNIC trial
| العنوان: | Early weight measures and long-term neuropsychological outcome of critically ill neonates and infants:a secondary analysis of the PEPaNIC trial |
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| المؤلفون: | Dijkhuizen, E. I., Dulfer, K., de Munck, S., van Haren, N. E.M., de Jonge, R. C.J., Vanhorebeek, I., Wouters, P. J., Van den Berghe, G., Verbruggen, S. C.A.T., Joosten, K. F.M. |
| المصدر: | Dijkhuizen , E I , Dulfer , K , de Munck , S , van Haren , N E M , de Jonge , R C J , Vanhorebeek , I , Wouters , P J , Van den Berghe , G , Verbruggen , S C A T & Joosten , K F M 2024 , ' Early weight measures and long-term neuropsychological outcome of critically ill neonates and infants : a secondary analysis of the PEPaNIC trial ' , European Journal of Pediatrics , vol. 183 , no. 2 , pp. 649-661 . https://doi.org/10.1007/s00431-023-05298-1Test |
| سنة النشر: | 2024 |
| الوصف: | Neonates and infants surviving critical illness show impaired growth during critical illness and are at risk for later neuropsychological impairments. Early identification of individuals most at risk is needed to provide tailored long-term follow-up and care. The research question is whether early growth during hospitalization is associated with growth and neuropsychological outcomes in neonates and infants after pediatric intensive care unit admission (PICU). This is a secondary analysis of the PEPaNIC trial. Weight measurements upon PICU admission, at PICU discharge, at hospital discharge, at 2- and 4-year follow-up, and of different subgroups were compared using (paired) t-tests. Multiple linear regression analyses were performed to investigate the association between early growth in weight measures and neuropsychological outcomes at 4-year follow-up. One hundred twenty-one infants were included, and median age upon admission was 21 days. Growth in weight per week was less than the age-appropriate norm, resulting in a decrease in weight-for-age Z-score during hospitalization. Weight is normalized at 2- and 4-year follow-up. Weight gain in kilograms per week and change in weight Z-score were not associated with neurodevelopmental outcome measures at 4-year follow-up. Lower weight-for-age Z-score at PICU admission and at hospital discharge was associated only with lower weight and height Z-scores at 4-year follow-up. Conclusion: Growth in weight during hospital stay of young survivors of critical illness is impaired. Worse early growth in weight is associated with lower weight and height but not with neuropsychological outcomes at 4-year follow-up. (Table presented.) |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://pure.eur.nl/en/publications/64c51b1f-59c5-4eba-b7e1-7e4a99e5dc54Test |
| DOI: | 10.1007/s00431-023-05298-1 |
| الإتاحة: | https://doi.org/10.1007/s00431-023-05298-1Test https://pure.eur.nl/en/publications/64c51b1f-59c5-4eba-b7e1-7e4a99e5dc54Test https://pure.eur.nl/ws/files/120060173/Early_weight_measures_and_long-term_neuropsychological_outcome_of_critically_ill_neonates_and_infants.pdfTest http://www.scopus.com/inward/record.url?scp=85176936956&partnerID=8YFLogxKTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.EAE02305 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s00431-023-05298-1 |
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