دورية أكاديمية
Standardization in laboratory medicine: Two years’ experience from category 1 EQA programs in Spain
| العنوان: | Standardization in laboratory medicine: Two years’ experience from category 1 EQA programs in Spain |
|---|---|
| المؤلفون: | Ricós, Carmen, Perich, Carmen, Boned, Beatriz, González-Lao, Elisabet, Diaz-Garzón, Jorge, Ventura, Montserrat, Bullich, Sandra, Corte, Zoraida, Minchinela, Joana, Marques, Fernando, Simón, Margarita, Alvarez, Virtudes, García-Lario, José-Vicente, Fernández-Fernández, Pilar, Fernández-Calle, Pilar |
| المصدر: | Biochemia Medica ; ISSN 1330-0962 (Print) ; ISSN 1846-7482 (Online) ; Volume 29 ; Issue 1 |
| بيانات النشر: | Medicinska naklada |
| سنة النشر: | 2019 |
| المجموعة: | Hrčak - Portal of scientific journals of Croatia / Portal znanstvenih časopisa Republike Hrvatske |
| مصطلحات موضوعية: | standardization, external quality assessment, traceability, bias |
| الوصف: | Introduction: Standardization is the ability to obtain interchangeable results leading to same medical interpretation. External quality assessment (EQA) is the main support of the on-going harmonization initiatives. Aim of study was to evaluate results obtained from two years category 1 EQA program experience in Spain and determine the impact of applying this type of EQA program on the analytical standardization. Materials and methods: According to the analytical method, traceability and instrument different groups were established which results were evaluated by calculating mean, coefficient of variation and percent of deviation to the reference value. Analytical performance specifications used to the results' evaluation were derived from biological variation for bias and from the inter-laboratory coefficients of variation found in a previous pilot study. Results: Only creatinine measured by enzymatic methods gave excellent results, although few laboratories used this method. Creatine kinase and GGT gave good precision and bias in all, but one instrument studied. For the remaining analytes (ALT, ALP, AST, bilirubin, calcium, chloride, glucose, magnesium, potassium, sodium, total protein and urate) some improvement is still necessary to achieve satisfactory standardization in our setting. Conclusions: The two years of category 1 EQA program experience in Spain have manifested a lack of standardization of 17 most frequent biochemistry tests used in our laboratories. The impact of the information obtained on the lack of standardization is to recommend abandoning methods such as ALT, AST without exogenous pyridoxal phosphate, Jaffe method for creatinine, and do not use non-commutable calibrators, such as aqueous solutions for calcium and sodium. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://hrcak.srce.hr/213855Test |
| الإتاحة: | https://doi.org/10.11613/BM.2019.010701Test https://hrcak.srce.hr/213855Test https://hrcak.srce.hr/file/312558Test |
| حقوق: | info:eu-repo/semantics/openAccess ; Full-text papers can be used for personal or educational purposes only. Authors' and publisher's copyrights must be acknowledged. |
| رقم الانضمام: | edsbas.EAB0ACE1 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |