التفاصيل البيبلوغرافية
| العنوان: |
Immune cell subsets in interface cutaneous immune‐related adverse events associated with anti‐PD‐1 therapy resemble acute graft versus host disease more than lichen planus |
| المؤلفون: |
Cruz, Guillermo E Almodovar, Kaunitz, Genevieve, Stein, Julie E, Sander, Inbal, Hollmann, Travis, Cottrell, Tricia R, Taube, Janis M, Sunshine, Joel C |
| المصدر: |
Journal of Cutaneous Pathology, vol 49, iss 8 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2022 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Aetiology, 2.1 Biological and endogenous factors, Inflammatory and immune system, Graft vs Host Disease, Humans, Immunohistochemistry, Lichen Planus, Skin, T-Lymphocytes, cutaneous eruptions, graft versus host disease, immune-related adverse events, immunologic markers, Clinical Sciences, Dermatology & Venereal Diseases |
| جغرافية الموضوع: |
701 - 708 |
| الوصف: |
BackgroundCheckpoint immunotherapy is frequently associated with cutaneous immune-related adverse events (cirAEs), and among those, the most common subtype shows interface reaction patterns that have been likened to lichen planus (LP); however, cutaneous acute graft versus host disease (aGVHD) may be a closer histopathologic comparator. We used quantitative pathology to compare the immunologic composition of anti-PD-1-associated interface reactions to LP and aGVHD to assess for similarities and differences between these cutaneous eruptions.MethodsImmunohistochemistry for CD4, CD8, CD68, PD-1, and PD-L1 was performed on formalin-fixed paraffin-embedded tissue from patients with anti-PD-1 interface cirAEs (n=4), LP (n=9), or aGVHD (n=5). Densities of immune cell subsets expressing each marker were quantified using the HALO image analysis immune cell module. Plasma cell and eosinophil density were quantified on routine H&E slides.ResultsSpecimens from patients with anti-PD-1 interface cirAEs showed equivalent total cell densities and immune cell composition to those with aGVHD. Patients with LP showed higher total immune cell infiltration, higher absolute T-cell densities, increased CD8 proportion, and reduced histiocytic component. The cases with the highest plasma cell counts were all anti-PD-1 interface cirAEs and aGVHD.ConclusionThe composition of immune cell subsets in anti-PD-1 interface cirAEs more closely resembles the immune response seen in aGVHD than LP within our cohort. This warrants a closer look via advanced analytics and may have implications for shared pathogenesis and potential treatment options. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt2rh2j7wx; https://escholarship.org/uc/item/2rh2j7wxTest |
| الإتاحة: |
https://escholarship.org/uc/item/2rh2j7wxTest |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.EAB0677D |
| قاعدة البيانات: |
BASE |
