التفاصيل البيبلوغرافية
| العنوان: |
Computer-based Eye-tracking Analysis of King-Devick Test Differentiates Persons with Idiopathic Normal Pressure Hydrocephalus from Cognitively Unimpaired |
| المؤلفون: |
Lehtola, Juha-Matti, Kärkkäinen, Virve, Andberg, Sami, Hannonen, Sanna, Rusanen, Minna, Saari, Toni, Korhonen, Ville, Hokkanen, Laura, Hallikainen, Merja, Hänninen, Tuomo, Kaarniranta, Kai, Bednarik, Roman, Leinonen, Ville, Koivisto, Anne M. |
| المساهمون: |
Department of Psychology and Logopedics, University of Helsinki, Department of Neurosciences, Clinicum, Helsinki University Hospital Area, Neurologian yksikkö |
| بيانات النشر: |
Lippincott Williams & Wilkins |
| سنة النشر: |
2023 |
| المجموعة: |
Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
| مصطلحات موضوعية: |
3112 Neurosciences, 3124 Neurology and psychiatry, 515 Psychology, Alzheimer's disease (AD), biomarker, eye tracking (ET), idiopathic normal pressure hydrocephalus (iNPH), King-Devick (KD), saccadic eye movements |
| الوصف: |
Background: Functional defects in eye movements and reduced reading speed in neurodegenerative diseases represent a potential new biomarker to support clinical diagnosis. We investigated whether computer-based eye-tracking (ET) analysis of the King-Devick (KD) test differentiates persons with idiopathic normal pressure hydrocephalus (iNPH) from cognitively unimpaired [control (CO)] and persons with Alzheimer's disease (AD). Methods: We recruited 68 participants (37 CO, 10 iNPH, and 21 AD) who underwent neurological examination, the Consortium to Establish a Registry for Alzheimer's Disease neuropsychological test battery (CERAD-NB), and a Clinical Dementia Rating interview. The KD reading test was performed using computer-based ET. We analyzed the total time used for the reading test, number of errors, durations of fixation and saccade, and saccade amplitudes. Results: The iNPH group significantly differed from the CO group in the KD test mean total time (CO 69.3 s, iNPH 87.3 s; P≤0.009) and eye-tracking recording of the mean saccade amplitude (CO 3.6 degree, iNPH 3.2 degree; P≤0.001). The AD group significantly differed from the CO group in each tested parameter. No significant differences were detected between the iNPH and AD groups. Conclusion: For the first time, we demonstrated altered reading ability and saccade amplitudes in patients with iNPH. ; Peer reviewed |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
The authors thank all study participants, statistician Tuomas Selander and study nurses Ulla Vanhanen, Kati Mönttinen, Kristiina Holopainen, Tarja Lappalainen, and Marita Parviainen. The authors are grateful to the Juho and Lempi Pitkänen foundation, the Maire Taponen Foundation, Maud Kuistila Foundation, Finnish Cultural Foundation, Finnish Brain Foundation and Finnish Government Research Funding for financial support.; Lehtola , J-M , Kärkkäinen , V , Andberg , S , Hannonen , S , Rusanen , M , Saari , T , Korhonen , V , Hokkanen , L , Hallikainen , M , Hänninen , T , Kaarniranta , K , Bednarik , R , Leinonen , V & Koivisto , A M 2022 , ' Computer-based Eye-tracking Analysis of King-Devick Test Differentiates Persons with Idiopathic Normal Pressure Hydrocephalus from Cognitively Unimpaired ' , Alzheimer Disease and Associated Disorders , vol. 36 , no. 4 , pp. 340-346 . https://doi.org/10.1097/WAD.0000000000000527Test; ORCID: /0000-0001-8342-9248/work/129615356; ORCID: /0000-0001-7721-3336/work/130606708; 85143088755; c4b61cbd-6a88-4c59-a3c0-3cd47a10da40; http://hdl.handle.net/10138/354870Test; 000923752200010 |
| الإتاحة: |
http://hdl.handle.net/10138/354870Test |
| حقوق: |
cc_by_nc_nd ; openAccess ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.EAAC005B |
| قاعدة البيانات: |
BASE |
