دورية أكاديمية
Postnatal Zika virus infection of nonhuman primate infants born to mothers infected with homologous Brazilian Zika virus
| العنوان: | Postnatal Zika virus infection of nonhuman primate infants born to mothers infected with homologous Brazilian Zika virus |
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| المؤلفون: | Maness, Nicholas J., Magnani, Diogo M |
| المساهمون: | MassBiologics |
| المصدر: | Scientific reports ; 9 ; 1 ; 12802 |
| سنة النشر: | 2022 |
| المجموعة: | University of Massachusetts, Medical School: eScholarship@UMMS |
| مصطلحات موضوعية: | Infectious diseases, Virology, Hemic and Immune Systems, Immunology and Infectious Disease, Infectious Disease, Viruses |
| الوصف: | Full author list omitted for brevity. For the full list of authors, see article. ; Recent data in a nonhuman primate model showed that infants postnatally infected with Zika virus (ZIKV) were acutely susceptible to high viremia and neurological damage, suggesting the window of vulnerability extends beyond gestation. In this pilot study, we addressed the susceptibility of two infant rhesus macaques born healthy to dams infected with Zika virus during pregnancy. Passively acquired neutralizing antibody titers dropped below detection limits between 2 and 3 months of age, while binding antibodies remained detectable until viral infection at 5 months. Acute serum viremia was comparatively lower than adults infected with the same Brazilian isolate of ZIKV (n = 11 pregnant females, 4 males, and 4 non-pregnant females). Virus was never detected in cerebrospinal fluid nor in neural tissues at necropsy two weeks after infection. However, viral RNA was detected in lymph nodes, confirming some tissue dissemination. Though protection was not absolute and our study lacks an important comparison with postnatally infected infants born to naive dams, our data suggest infants born healthy to infected mothers may harbor a modest but important level of protection from postnatally acquired ZIKV for several months after birth, an encouraging result given the potentially severe infection outcomes of this population. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | Link to Article in PubMed; Sci Rep. 2019 Sep 5;9(1):12802. doi:10.1038/s41598-019-49209-7. Link to article on publisher's site; 2045-2322 (Linking); http://hdl.handle.net/20.500.14038/41220Test; https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=5021&context=oapubs&unstamped=1Test; https://escholarship.umassmed.edu/oapubs/4004Test; oapubs/4004 |
| DOI: | 10.1038/s41598-019-49209-7 |
| الإتاحة: | https://doi.org/10.1038/s41598-019-49209-7Test https://doi.org/20.500.14038/41220Test https://hdl.handle.net/20.500.14038/41220Test https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=5021&context=oapubs&unstamped=1Test https://escholarship.umassmed.edu/oapubs/4004Test |
| حقوق: | Copyright © The Author(s) 2019. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0Test/. ; http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.EA4BB136 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41598-019-49209-7 |
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