دورية أكاديمية
Is bisphenol S a safer alternative to bisphenol A in terms of potential fetal exposure ? Placental transfer across the perfused human placenta.
| العنوان: | Is bisphenol S a safer alternative to bisphenol A in terms of potential fetal exposure ? Placental transfer across the perfused human placenta. |
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| المؤلفون: | Grandin, Flore C., Viguié, Catherine, Lacroix, Marlène Z., Gayrard-Troy, Véronique, V., Mila, Hanna, de Place, Alice, Vayssière, Christophe, Morin, Mathieu, Corbett, Julie, Gayrard, Cécile, Gely, Clémence, Toutain, Pierre-Louis, Picard-Hagen, Nicole |
| المساهمون: | ToxAlim (ToxAlim), Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Ecole d'Ingénieurs de Purpan (INP - PURPAN), Université de Toulouse (UT)-Université de Toulouse (UT), Exposition, Perturbation Endocrino-métabolique et Reproduction (ToxAlim-EXPER), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Innovations Thérapeutiques et Résistances (InTheRes), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT), Royal Veterinary College London, University of London London |
| المصدر: | ISSN: 0045-6535. |
| بيانات النشر: | HAL CCSD Elsevier |
| سنة النشر: | 2019 |
| المجموعة: | Université Toulouse III - Paul Sabatier: HAL-UPS |
| مصطلحات موضوعية: | Bisphenol A, Bisphenol S, Endocrine disruptor, Bisphenol S glucuronide, Human placental transport, [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; The aim of our study was to evaluate the bidirectional transfer of Bisphenol S (BPS) and its main metabolite, BPS Glucuronide (BPSG), using the model of perfused human placenta and to compare the obtained values with those of Bisphenol A (BPA) and BPA Glucuronide. Fourteen placentas at term were perfused in an open dual circuit with deuterated BPS (1 and 5 μM) and non-labelled BPSG (2.5 μM) and a freely diffusing marker antipyrine (800 ng/ml) in the presence of albumin (25 mg/ml). In a second experiment, the potential role of P-glycoprotein in the active efflux of BPS across the placental barrier was studied using the well-established P-glycoprotein inhibitor, PSC833 (2 and 4 μM). Placental transfer of BPS was much lower than that of BPA in both directions. The placental clearance index of BPS in the materno-fetal direction was three times lower than in the opposite direction, strongly suggesting some active efflux transport. However, our results show that P-glycoprotein is not involved in limiting the materno-fetal transfer of BPS. Placental transfer of BPSG in the fetal compartment was almost non-existent indicating that, in the fetal compartment, BPSG originates mainly from feto-placental metabolism. The feto-maternal clearance index for BPSG was 20-fold higher than the materno-fetal index. We conclude that the blood-placental barrier is much more efficient in limiting fetal exposure to BPS than to BPA, indicating that the placenta has a crucial role in protecting the human fetus from BPS exposure. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/30654261; hal-02626596; https://hal.inrae.fr/hal-02626596Test; https://hal.inrae.fr/hal-02626596/documentTest; https://hal.inrae.fr/hal-02626596/file/S0045653519300657.pdfTest; PII: S0045-6535(19)30065-7; PRODINRA: 458316; PUBMED: 30654261; WOS: 000460710700052 |
| DOI: | 10.1016/j.chemosphere.2019.01.065 |
| الإتاحة: | https://doi.org/10.1016/j.chemosphere.2019.01.065Test https://hal.inrae.fr/hal-02626596Test https://hal.inrae.fr/hal-02626596/documentTest https://hal.inrae.fr/hal-02626596/file/S0045653519300657.pdfTest |
| حقوق: | http://creativecommons.org/licenses/by-ncTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.EA3B2568 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.chemosphere.2019.01.065 |
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