التفاصيل البيبلوغرافية
| العنوان: |
A novel NMDA receptor test model based on hiPSC-derived neural cells |
| المؤلفون: |
Disse, Paul, Aymanns, Isabel, Ritter, Nadine, Peischard, Stefan, Korn, Lisanne, Wiendl, Heinz, Pawlowski, Matthias, Kovac, Stjepana, Meuth, Sven G., Budde, Thomas, Strutz-Seebohm, Nathalie, Wünsch, Bernhard, Seebohm, Guiscard |
| المساهمون: |
Deutsche Forschungsgemeinschaft |
| المصدر: |
Biological Chemistry ; volume 404, issue 4, page 267-277 ; ISSN 1431-6730 1437-4315 |
| بيانات النشر: |
Walter de Gruyter GmbH |
| سنة النشر: |
2023 |
| الوصف: |
N -Methyl- D -aspartate receptors (NMDARs) are central for learning and information processing in the brain. Dysfunction of NMDARs can play a key role in the pathogenesis of neurodegeneration and drug addiction. The development of selective NMDAR modulators represents a promising strategy to target these diseases. Among such modulating compounds are ifenprodil and its 3-benzazepine derivatives. Classically, the effects of these NMDAR modulators have been tested by techniques like two-electrode voltage clamp (TEVC), patch clamp, or fluorescence-based assays. However, testing their functional effects in complex human systems requires more advanced approaches. Here, we established a human induced pluripotent stem cell-derived (hiPSC-derived) neural cell system and proved its eligibility as a test system for investigating NMDAR modulators and pharmaceutical effects on human neurons. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1515/hsz-2022-0216 |
| DOI: |
10.1515/hsz-2022-0216/xml |
| DOI: |
10.1515/hsz-2022-0216/pdf |
| الإتاحة: |
https://doi.org/10.1515/hsz-2022-0216Test |
| رقم الانضمام: |
edsbas.E9D3E224 |
| قاعدة البيانات: |
BASE |
