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Variation of BMP3 contributes to dog breed skull diversity.

التفاصيل البيبلوغرافية
العنوان: Variation of BMP3 contributes to dog breed skull diversity.
المؤلفون: Jeffrey J Schoenebeck, Sarah A Hutchinson, Alexandra Byers, Holly C Beale, Blake Carrington, Daniel L Faden, Maud Rimbault, Brennan Decker, Jeffrey M Kidd, Raman Sood, Adam R Boyko, John W Fondon, Robert K Wayne, Carlos D Bustamante, Brian Ciruna, Elaine A Ostrander
المصدر: PLoS Genetics, Vol 8, Iss 8, p e1002849 (2012)
بيانات النشر: Public Library of Science (PLoS)
سنة النشر: 2012
المجموعة: Directory of Open Access Journals: DOAJ Articles
مصطلحات موضوعية: Genetics, QH426-470
الوصف: Since the beginnings of domestication, the craniofacial architecture of the domestic dog has morphed and radiated to human whims. By beginning to define the genetic underpinnings of breed skull shapes, we can elucidate mechanisms of morphological diversification while presenting a framework for understanding human cephalic disorders. Using intrabreed association mapping with museum specimen measurements, we show that skull shape is regulated by at least five quantitative trait loci (QTLs). Our detailed analysis using whole-genome sequencing uncovers a missense mutation in BMP3. Validation studies in zebrafish show that Bmp3 function in cranial development is ancient. Our study reveals the causal variant for a canine QTL contributing to a major morphologic trait.
نوع الوثيقة: article in journal/newspaper
اللغة: English
تدمد: 1553-7390
1553-7404
العلاقة: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22876193/pdf/?tool=EBITest; https://doaj.org/toc/1553-7390Test; https://doaj.org/toc/1553-7404Test; https://doaj.org/article/da65ca9d6a76427a9ce911d89d9ba5caTest
DOI: 10.1371/journal.pgen.1002849
الإتاحة: https://doi.org/10.1371/journal.pgen.1002849Test
https://doaj.org/article/da65ca9d6a76427a9ce911d89d9ba5caTest
رقم الانضمام: edsbas.E9C80C6B
قاعدة البيانات: BASE
الوصف
تدمد:15537390
15537404
DOI:10.1371/journal.pgen.1002849