دورية أكاديمية
Hepatitis C Virus (HCV) Clearance After Treatment With Direct-Acting Antivirals in Human Immunodeficiency Virus (HIV)-HCV Coinfection Modulates Systemic Immune Activation and HIV Transcription on Antiretroviral Therapy
| العنوان: | Hepatitis C Virus (HCV) Clearance After Treatment With Direct-Acting Antivirals in Human Immunodeficiency Virus (HIV)-HCV Coinfection Modulates Systemic Immune Activation and HIV Transcription on Antiretroviral Therapy |
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| المؤلفون: | Ghiglione, Yanina, Polo, María Laura, Urioste, Alejandra, Rhodes, Ajantha, Czernikier, Alejandro, Trifone, César, Quiroga, María Florencia, Sisto, Alicia, Patterson, Patricia, Salomón, Horacio, Rolón, María José, Bakkour, Sonia, Lewin, Sharon R, Turk, Gabriela, Laufer, Natalia |
| المساهمون: | National Health and Medical Research Council of Australia, National Institutes for Health Delaney AIDS Research Enterprise, Consejo Nacional de Investigaciones Científicas y Técnicas, Agencia Nacional de Promoción Científica y Tecnológica, ViiV Healthcare Investigator Sponsored Studies, Fundación Florencio Fiorini |
| المصدر: | Open Forum Infectious Diseases ; volume 7, issue 5 ; ISSN 2328-8957 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Infectious Diseases, Oncology |
| الوصف: | Background Hepatitis C virus (HCV) coinfection among people with human immunodeficiency virus (HIV) might perturb immune function and HIV persistence. We aimed to evaluate the impact of HCV clearance with direct-acting antivirals (DAAs) on immune activation and HIV persistence in HIV/HCV-coinfected individuals on antiretroviral therapy (ART). Methods In a prospective observational study, ART-treated participants with HIV/HCV coinfection received sofosbuvir/daclatasvir ± ribavirin (n = 19). Blood samples were collected before DAA therapy, at the end of treatment, and 12 months after DAA termination (12MPT). T- and natural killer (NK)-cell phenotype, soluble plasma factors, cell-associated (CA)-HIV deoxyribonucleic acid (DNA) forms (total, integrated, 2LTR), CA-unspliced (US) and multiple-spliced ribonucleic acid (RNA), and plasma HIV RNA were evaluated. Results Hepatitis C virus clearance was associated with (1) a downmodulation of activation and exhaustion markers in CD4+, CD8+ T, and NK cells together with (2) decreased plasma levels of Interferon gamma-induced protein 10 (IP10), interleukin-8 (IL-8), soluble (s)CD163 and soluble intercellular adhesion molecule (sICAM). Cell-associated US HIV RNA was significantly higher at 12MPT compared to baseline, with no change in HIV DNA or plasma RNA. Conclusions Elimination of HCV in HIV/HCV-coinfected individuals alters immune function and the transcriptional activity of latently infected cells. This report provides insights into the effects of HCV coinfection in HIV persistence and regards coinfected subjects as a population in which HIV remission might prove to be more challenging. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/ofid/ofaa115 |
| DOI: | 10.1093/ofid/ofaa115/32992409/ofaa115.pdf |
| الإتاحة: | https://doi.org/10.1093/ofid/ofaa115Test http://academic.oup.com/ofid/article-pdf/7/5/ofaa115/33172539/ofaa115.pdfTest |
| حقوق: | http://creativecommons.org/licenses/by-nc-nd/4.0Test/ |
| رقم الانضمام: | edsbas.E9A76FA4 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/ofid/ofaa115 |
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