دورية أكاديمية
Oxygen deteriorates arterial function in type 1 diabetes
| العنوان: | Oxygen deteriorates arterial function in type 1 diabetes |
|---|---|
| المؤلفون: | Gordin, D., Bernardi, L., Rosengård-Bärlund, M., Mäkinen, V., Soro-Paavonen, A., Forsblom, C., Sandelin, A., Groop, P. |
| المصدر: | http://dx.doi.org/10.1007/s00592-015-0775-3Test. |
| بيانات النشر: | Springer-Verlag |
| سنة النشر: | 2016 |
| المجموعة: | The University of Adelaide: Digital Library |
| مصطلحات موضوعية: | Augmentation index, blood pressure, hyperoxia, oxygen, pulse wave velocity, type 1 diabetes |
| الوصف: | Although oxygen is commonly used to treat various medical conditions, it has recently been shown to worsen vascular function (arterial stiffness) in healthy volunteers and even more in patients in whom vascular function might already be impaired. The effects of oxygen on arterial function in patients with type 1 diabetes (T1D) are unknown, although such patients display disturbed vascular function already at rest. Therefore, we tested whether short-term oxygen administration may alter the arterial function in patients with T1D.We estimated arterial stiffness by augmentation index (AIx) and the pulse wave velocity equivalent (SI-DVP) in 98 patients with T1D and 49 age- and sex-matched controls at baseline and during hyperoxia by obtaining continuous noninvasive finger pressure waveforms using a recently validated method.AIx and SI-DVP increased in patients (P < 0.05) but not in controls in response to hyperoxia. The increase in AIx (P = 0.05), systolic (P < 0.05), and diastolic (P < 0.05) blood pressure was higher in the patients than in the controls.Short-term oxygen administration deteriorates arterial function in patients with T1D compared to non-diabetic control subjects. Since disturbed arterial function plays a major role in the development of diabetic complications, these findings may be of clinical relevance. ; Daniel Gordin, Luciano Bernardi, Milla Rosengård-Bärlund, Ville-Petteri Ma, kinen, Aino Soro-Paavonen, Carol Forsblom, Anna Sandelin, Per-Henrik Groop |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0940-5429 1432-5233 |
| العلاقة: | Acta Diabetologica: an international journal devoted to the study of clinical and experimental diabetes and metabolism, 2016; 53(3):349-357; http://hdl.handle.net/2440/118554Test |
| DOI: | 10.1007/s00592-015-0775-3 |
| الإتاحة: | https://doi.org/10.1007/s00592-015-0775-3Test http://hdl.handle.net/2440/118554Test |
| حقوق: | © Springer-Verlag Italia 2015 |
| رقم الانضمام: | edsbas.E94CE588 |
| قاعدة البيانات: | BASE |
| تدمد: | 09405429 14325233 |
|---|---|
| DOI: | 10.1007/s00592-015-0775-3 |