دورية أكاديمية
Impact of Nanoparticles on Male Fertility: What Do We Really Know? A Systematic Review
| العنوان: | Impact of Nanoparticles on Male Fertility: What Do We Really Know? A Systematic Review |
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| المؤلفون: | Klein, Jean-Philippe, Mery, Lionel, Boudard, Delphine, Ravel, Célia, Cottier, Michèle, Bitounis, Dimitrios |
| المساهمون: | Centre Hospitalier Universitaire de Saint-Etienne CHU Saint-Etienne (CHU ST-E), Santé Ingénierie Biologie Saint-Etienne (SAINBIOSE), Centre Ingénierie et Santé (CIS-ENSMSE), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom Paris (IMT)-Institut Mines-Télécom Paris (IMT)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom Paris (IMT)-Institut Mines-Télécom Paris (IMT)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Ponchaillou, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique EHESP (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École des Hautes Études en Santé Publique EHESP (EHESP) |
| المصدر: | ISSN: 1661-6596. |
| بيانات النشر: | HAL CCSD MDPI |
| سنة النشر: | 2023 |
| المجموعة: | Université Jean Monnet – Saint-Etienne: HAL |
| مصطلحات موضوعية: | nanosized objects, testicular biodistribution, reprotoxicity, blood-testis barrier, [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; The real impact of nanoparticles on male fertility is evaluated after a careful analysis of the available literature. The first part reviews animal models to understand the testicular biodistribution and biopersistence of nanoparticles, while the second part evaluates their in vitro and in vivo biotoxicity. Our main findings suggest that nanoparticles are generally able to reach the testicle in small quantities where they persist for several months, regardless of the route of exposure. However, there is not enough evidence that they can cross the blood-testis barrier. Of note, the majority of nanoparticles have low direct toxicity to the testis, but there are indications that some might act as endocrine disruptors. Overall, the impact on spermatogenesis in adults is generally weak and reversible, but exceptions exist and merit increased attention. Finally, we comment on several methodological or analytical biases which have led some studies to exaggerate the reprotoxicity of nanoparticles. In the future, rigorous clinical studies in tandem with mechanistic studies are needed to elucidate the real risk posed by nanoparticles on male fertility. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/36614018; hal-03967605; https://hal.science/hal-03967605Test; https://hal.science/hal-03967605/documentTest; https://hal.science/hal-03967605/file/ijms-24-00576.pdfTest; PUBMED: 36614018 |
| DOI: | 10.3390/ijms24010576 |
| الإتاحة: | https://doi.org/10.3390/ijms24010576Test https://hal.science/hal-03967605Test https://hal.science/hal-03967605/documentTest https://hal.science/hal-03967605/file/ijms-24-00576.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.E915E15C |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/ijms24010576 |
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