دورية أكاديمية
Could Mycolactone Inspire New Potent Analgesics? Perspectives and Pitfalls
| العنوان: | Could Mycolactone Inspire New Potent Analgesics? Perspectives and Pitfalls |
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| المؤلفون: | Reynaert, Marie-Line, Dupoiron, Denis, Yeramian, Edouard, Marsollier, Laurent, C, Brodin, Priscille |
| المساهمون: | Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 (CIIL), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), Institut de Cancérologie de l'Ouest Angers/Nantes (UNICANCER/ICO), UNICANCER, Microbiologie structurale - Structural Microbiology (Microb. Struc. (UMR_3528 / U-Pasteur_5)), Institut Pasteur Paris (IP)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), ATOMycA (CRCINA-ÉQUIPE 6), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Financial support for this work was provided by the region Pays de la Loire (Kalmos project), the Agence Nationale de Recherche (ANR-17-CE18-0001), the Institut Pasteur of Lille (granted to P.B. and M.L.R.), the Inserm Program ATIP avenir (granted to L.M), the region Pays de la Loire (Kalmos project) and Angers University., ANR-17-CE18-0001,AT2R-TRAAK-BIOANALGESICS,Caractérisations moléculaires et cellulaires de voies de signalisation de la douleur: contrôle de la douleur dans l'ulcère de buruli comme source d'inspiration pour la conception rationnelle de nouveaux analgésiques puissants(2017) |
| المصدر: | EISSN: 2072-6651 ; Toxins ; https://inserm.hal.science/inserm-02284632Test ; Toxins, 2019, 11 (9), pp.516. ⟨10.3390/toxins11090516⟩ |
| بيانات النشر: | HAL CCSD MDPI |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | AT2R, drug development, neurons, analgesia, mycolactone, [SDV.CAN]Life Sciences [q-bio]/Cancer |
| الوصف: | International audience ; Pain currently represents the most common symptom for which medical attention is sought by patients. The available treatments have limited effectiveness and significant side-effects. In addition, most often, the duration of analgesia is short. Today, the handling of pain remains a major challenge. One promising alternative for the discovery of novel potent analgesics is to take inspiration from Mother Nature; in this context, the detailed investigation of the intriguing analgesia implemented in Buruli ulcer, an infectious disease caused by the bacterium Mycobacterium ulcerans and characterized by painless ulcerative lesions, seems particularly promising. More precisely, in this disease, the painless skin ulcers are caused by mycolactone, a polyketide lactone exotoxin. In fact, mycolactone exerts a wide range of effects on the host, besides being responsible for analgesia, as it has been shown notably to modulate the immune response or to provoke apoptosis. Several cellular mechanisms and different targets have been proposed to account for the analgesic effect of the toxin, such as nerve degeneration, the inhibition of inflammatory mediators and the activation of angiotensin II receptor 2. In this review, we discuss the current knowledge in the field, highlighting possible controversies. We first discuss the different pain-mimicking experimental models that were used to study the effect of mycolactone. We then detail the different variants of mycolactone that were used in such models. Overall, based on the results and the discussions, we conclude that the development of mycolactone-derived molecules can represent very promising perspectives for new analgesic drugs, which could be effective for specific pain indications. Key Contribution: This review develops arguments and issues around the development of new potent analgesic drugs derived from mycolactone, a toxin secreted by Mycobacterium ulcerans. To this end, the various modes of action of the toxin potentially underlying its analgesic ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/31487908; inserm-02284632; https://inserm.hal.science/inserm-02284632Test; https://inserm.hal.science/inserm-02284632/documentTest; https://inserm.hal.science/inserm-02284632/file/Marsollier2019Eq6.pdfTest; PUBMED: 31487908 |
| DOI: | 10.3390/toxins11090516 |
| الإتاحة: | https://doi.org/10.3390/toxins11090516Test https://inserm.hal.science/inserm-02284632Test https://inserm.hal.science/inserm-02284632/documentTest https://inserm.hal.science/inserm-02284632/file/Marsollier2019Eq6.pdfTest |
| حقوق: | http://creativecommons.org/licenses/byTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.E8E6907 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/toxins11090516 |
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