دورية أكاديمية
Two independent variants of epidermal growth factor receptor associated with risk of glioma in a Korean population
| العنوان: | Two independent variants of epidermal growth factor receptor associated with risk of glioma in a Korean population |
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| المساهمون: | In Ki Baek, Hyun Sub Cheong, Seok Namgoong, Jeong-Hyun Kim, Seok-Gu Kang, Seon-Jin Yoon, Se Hoon Kim, Jong Hee Chang, Lyoung Hyo Kim, Hyoung Doo Shin, Kang, Seok Gu |
| بيانات النشر: | Nature Publishing Group |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Brain Neoplasms* / epidemiology, Brain Neoplasms* / genetics, Case-Control Studies, ErbB Receptors / genetics, Genetic Predisposition to Disease, Glioma* / epidemiology, Glioma* / genetics, Humans, Polymorphism, Single Nucleotide, Republic of Korea / epidemiology, Risk Factors |
| الوصف: | Gliomas are the most common primary tumors in the brain and spinal cord. In previous GWASs, SNPs in epidermal growth factor receptor (EGFR) have been reported as risk loci for gliomas. However, EGFR variants associated with gliomas in the Korean population remain unstudied. This study explored the association of EGFR SNPs with the risk of glioma. We genotyped 13 EGFR exon SNPs in a case-control study that included 324 Korean patients diagnosed with glioma and 480 population-based controls. Statistical analyses of the association between EGFR SNPs and glioma risk were conducted using logistic regression. Both stepwise analysis and conditional logistic analysis were performed to identify independent associations among genotyped variants. We confirmed that two SNPs (rs2227983, rs1050171) were significantly associated with glioma (rs2227983: odds ratio = 1.42, Pcorr = 0.009; rs1050171: odds ratio = 1.68, Pcorr = 0.005). Additionally, the stepwise analysis and conditional logistic analysis indicated that both SNPs created variants with independent genetic effects. This study is the first to show evidence that functional variants of EGFR, namely, rs2227983 (K521R) and rs1050171 (Q787Q), are associated with an increased risk of glioma in the Korean population. Future work should confirm the functional association between EGFR variants and glioma. ; open |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2045-2322 |
| العلاقة: | SCIENTIFIC REPORTS; J02646; OAK-2022-08646; OAK-2022-08647; OAK-2022-08648; https://ir.ymlib.yonsei.ac.kr/handle/22282913/192337Test; T202205516; SCIENTIFIC REPORTS, Vol.12(1) : 19014, 2022-11 |
| DOI: | 10.1038/s41598-022-23217-6 |
| الإتاحة: | https://doi.org/10.1038/s41598-022-23217-6Test https://ir.ymlib.yonsei.ac.kr/handle/22282913/192337Test |
| حقوق: | CC BY-NC-ND 2.0 KR |
| رقم الانضمام: | edsbas.E883FFEB |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-022-23217-6 |