دورية أكاديمية
Database search strategies.
| العنوان: | Database search strategies. |
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| المؤلفون: | Luzia T. Freitas, Mashroor Ahmad Khan, Azhar Uddin, Julia B. Halder, Sauman Singh-Phulgenda, Jeyapal Dinesh Raja, Vijayakumar Balakrishnan, Eli Harriss, Manju Rahi, Matthew Brack, Philippe J. Guérin, Maria-Gloria Basáñez, Ashwani Kumar, Martin Walker, Adinarayanan Srividya |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | Medicine, Pharmacology, Biotechnology, Cancer, Science Policy, Infectious Diseases, Virology, Computational Biology, world health organization, urgent questions could, searched literature published, public health problem, mass drug administration, least one occasion, circulating filarial antigen, adverse event outcomes, 9 billion treatments, related ipd suggest, 940 ipd cover, 4 %) ipd, ultrasound indicators measured, th , st , new studies using, identified 33 studies, 72 endemic countries, 6 %) ipd, systematic literature review, neglected tropical disease, morbidity outcomes measured |
| الوصف: | Background Lymphatic filariasis (LF) is a neglected tropical disease (NTD) targeted by the World Health Organization for elimination as a public health problem (EPHP). Since 2000, more than 9 billion treatments of antifilarial medicines have been distributed through mass drug administration (MDA) programmes in 72 endemic countries and 17 countries have reached EPHP. Yet in 2021, nearly 900 million people still required MDA with combinations of albendazole, diethylcarbamazine and/or ivermectin. Despite the reliance on these drugs, there remain gaps in understanding of variation in responses to treatment. As demonstrated for other infectious diseases, some urgent questions could be addressed by conducting individual participant data (IPD) meta-analyses. Here, we present the results of a systematic literature review to estimate the abundance of IPD on pre- and post-intervention indicators of infection and/or morbidity and assess the feasibility of building a global data repository. Methodology We searched literature published between 1 st January 2000 and 5 th May 2023 in 15 databases to identify prospective studies assessing LF treatment and/or morbidity management and disease prevention (MMDP) approaches. We considered only studies where individual participants were diagnosed with LF infection or disease and were followed up on at least one occasion after receiving an intervention/treatment. Principal findings We identified 138 eligible studies from 23 countries, having followed up an estimated 29,842 participants after intervention. We estimate 14,800 (49.6%) IPD on pre- and post-intervention infection indicators including microfilaraemia, circulating filarial antigen and/or ultrasound indicators measured before and after intervention using 8 drugs administered in various combinations. We identified 33 studies on MMDP, estimating 6,102 (20.4%) IPD on pre- and post-intervention clinical morbidity indicators only. A further 8,940 IPD cover a mixture of infection and morbidity outcomes measured with other ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | https://figshare.com/articles/journal_contribution/Database_search_strategies_/25007872Test |
| DOI: | 10.1371/journal.pntd.0011882.s001 |
| الإتاحة: | https://doi.org/10.1371/journal.pntd.0011882.s001Test https://figshare.com/articles/journal_contribution/Database_search_strategies_/25007872Test |
| حقوق: | CC BY 4.0 |
| رقم الانضمام: | edsbas.E87610AA |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pntd.0011882.s001 |
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