دورية أكاديمية
Correlation between blood telomere length and CD4+ CD8+ T-cell subsets changes 96 weeks after initiation of antiretroviral therapy in HIV-1-positive individuals.
| العنوان: | Correlation between blood telomere length and CD4+ CD8+ T-cell subsets changes 96 weeks after initiation of antiretroviral therapy in HIV-1-positive individuals. |
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| المؤلفون: | Chalouni, Mathieu, Rodriguez-Centeno, Javier, Samri, Assia, Blanco, Julian, Stella-Ascariz, Natalia, Wallet, Cedrick, Knobel, Hernando, Zucman, David, Autran, Brigitte, Thiebaut, Rodolphe, Raffi, François, Arribas, José Ramón, Alejos, Belén |
| المساهمون: | Red de Investigación Cooperativa en Investigación en Sida (España), Instituto de Salud Carlos III, Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) |
| بيانات النشر: | Public Library of Science (PLOS) |
| سنة النشر: | 2020 |
| المجموعة: | REPISALUD (REPositorio Institucional en SALUD del Instituto de Salud Carlos III - ISCIII) |
| مصطلحات موضوعية: | ADP-ribosyl Cyclase 1, Adult, Anti-Retroviral Agents, Antiretroviral Therapy, Highly Active, CD4 Lymphocyte Count, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Female, HIV Infections, HIV Seropositivity, HIV-1, Humans, Immunologic Memory, Immunophenotyping, Lymphocyte Activation, Male, Middle Aged, T-Lymphocyte Subsets, Telomere, Viral Load |
| الوصف: | In 31 participants who started first-line antiretroviral therapy in the NEAT 001/ANRS 143 clinical trial, we found after 96 weeks a statistically significant increase in blood telomere length (TL) of 0.04 (T/S Ratio) (p = 0.03). This increase was positively correlated with both the change in the percentage of CD4+ T-cells and with the decrease of CD38+ molecules on Central Memory CD8+ and negatively correlated with the change in the percentage of CD4+ Effector Memory cells. Increase in TL could be an expression of immune reconstitution and the associated decrease in immune activation. We acknowledge for the low statistical power due to the small sample size and the potential for false positive results due to multiple testing. Hence, further studies are needed to confirm these observations. ; This work was supported by NEAT-ID Foundation (not for profit private foundation to promote research and education projects in the HIV field); Red Temática Cooperativa de Investigación en Sida; and Fondo de Investigaciones Sanitarias (supported by FEDER funds; grant number PI13/01467) The NEAT 001/ANRS 143 trial was supported by Gilead Sciences, Janssen Pharmaceuticals, and Merck Laboratories. French National Institute for Health and Medical Research–France Recherche Nord and Sud Sida- HIV Hepatites (Inserm-ANRS) was the sponsor and a founder of the trial. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the ; Sí |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1932-6203 |
| العلاقة: | https://doi.org/10.1371/journal.pone.0230772Test; info:eu_repo/grantAgreement/ES/PI13/01467; PLoS One . 2020 Apr 8;15(4):e0230772.; http://hdl.handle.net/20.500.12105/10857Test; PloS one |
| DOI: | 10.1371/journal.pone.0230772 |
| الإتاحة: | https://doi.org/20.500.12105/10857Test https://doi.org/10.1371/journal.pone.0230772Test https://hdl.handle.net/20.500.12105/10857Test |
| حقوق: | http://creativecommons.org/licenses/by/4.0Test/ ; Atribución 4.0 Internacional ; open access |
| رقم الانضمام: | edsbas.E827FFB7 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0230772 |