دورية أكاديمية
CarDiac magnEtic Resonance for prophylactic Implantable-cardioVerter defibrillAtor ThErapy in Non-Ischaemic dilated CardioMyopathy: An international Registry
| العنوان: | CarDiac magnEtic Resonance for prophylactic Implantable-cardioVerter defibrillAtor ThErapy in Non-Ischaemic dilated CardioMyopathy: An international Registry |
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| المؤلفون: | Guaricci A. I., Masci P. G., Muscogiuri G., Guglielmo M., Baggiano A., Fusini L., Lorenzoni V., Martini C., Andreini D., Pavon A. G., Aquaro G. D., Barison A., Todiere G., Rabbat M. G., Tat E., Raineri C., Valentini A., Varga-Szemes A., Schoepf U. J., De Cecco C. N., Bogaert J., Dobrovie M., Symons R., Focardi M., Gismondi A., Lozano-Torres J., Rodriguez-Palomares J. F., Lanzillo C., Di Roma M., Moro C., Di Giovine G., Margonato D., De Lazzari M., Perazzolo Marra M., Nese A., Casavecchia G., Gravina M., Marzo F., Carigi S., Pica S., Lombardi M., Censi S., Squeri A., Palumbo A., Gaibazzi N., Camastra G., Sbarbati S., Pedrotti P., Masi A., Carrabba N., Pradella S., Timpani M., Cicala G., Presicci C., Puglisi S., Sverzellati N., Santobuono V. E., Pepi M., Schwitter J., Pontone G. |
| المساهمون: | A.I. Guaricci, P.G. Masci, G. Muscogiuri, M. Guglielmo, A. Baggiano, L. Fusini, V. Lorenzoni, C. Martini, D. Andreini, A.G. Pavon, G.D. Aquaro, A. Barison, G. Todiere, M.G. Rabbat, E. Tat, C. Raineri, A. Valentini, A. Varga-Szeme, U.J. Schoepf, C.N. De Cecco, J. Bogaert, M. Dobrovie, R. Symon, M. Focardi, A. Gismondi, J. Lozano-Torre, J.F. Rodriguez-Palomare, C. Lanzillo, M. Di Roma, C. Moro, G. Di Giovine, D. Margonato, M. De Lazzari, M. Perazzolo Marra, A. Nese, G. Casavecchia, M. Gravina, F. Marzo, S. Carigi, S. Pica, M. Lombardi, S. Censi, A. Squeri, A. Palumbo, N. Gaibazzi, G. Camastra, S. Sbarbati, P. Pedrotti, A. Masi, N. Carrabba, S. Pradella, M. Timpani, G. Cicala, C. Presicci, S. Puglisi, N. Sverzellati, V.E. Santobuono, M. Pepi, J. Schwitter, G. Pontone |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2021 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | Cardiac magnetic resonance, Heart failure, Implantable cardioverter-defibrillator, Non-ischaemic dilated cardiomyopathy, Primary prevention, Contrast Media, Female, Gadolinium, Human, Magnetic Resonance Imaging, Cine, Magnetic Resonance Spectroscopy, Male, Predictive Value of Test, Prognosi, Registrie, Stroke Volume, Ventricular Function, Left, Cardiomyopathy, Dilated, Defibrillators, Implantable, Settore MED/11 - Malattie dell'Apparato Cardiovascolare |
| الوصف: | Aims: The aim of this registry was to evaluate the additional prognostic value of a composite cardiac magnetic resonance (CMR)-based risk score over standard-of-care (SOC) evaluation in a large cohort of consecutive unselected non-ischaemic cardiomyopathy (NICM) patients. Methods and results: In the DERIVATE registry (www.clinicaltrials.gov/registration: RCT#NCT03352648), 1000 (derivation cohort) and 508 (validation cohort) NICM patients with chronic heart failure (HF) and left ventricular ejection fraction <50% were included. All-cause mortality and major adverse arrhythmic cardiac events (MAACE) were the primary and secondary endpoints, respectively. During a median follow-up of 959 days, all-cause mortality and MAACE occurred in 72 (7%) and 93 (9%) patients, respectively. Age and >3 segments with midwall fibrosis on late gadolinium enhancement (LGE) were the only independent predictors of all-cause mortality (HR: 1.036, 95% CI: 1.0117-1.056, P < 0.001 and HR: 2.077, 95% CI: 1.211-3.562, P = 0.008, respectively). For MAACE, the independent predictors were male gender, left ventricular end-diastolic volume index by CMR (CMR-LVEDVi), and >3 segments with midwall fibrosis on LGE (HR: 2.131, 95% CI: 1.231-3.690, P = 0.007; HR: 3.161, 95% CI: 1.750-5.709, P < 0.001; and HR: 1.693, 95% CI: 1.084-2.644, P = 0.021, respectively). A composite clinical and CMR-based risk score provided a net reclassification improvement of 63.7% (P < 0.001) for MAACE occurrence when added to the model based on SOC evaluation. These findings were confirmed in the validation cohort. Conclusion: In a large multicentre, multivendor cohort registry reflecting daily clinical practice in NICM work-up, a composite clinical and CMR-based risk score provides incremental prognostic value beyond SOC evaluation, which may have impact on the indication of implantable cardioverter-defibrillator implantation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/33792661; info:eu-repo/semantics/altIdentifier/wos/WOS:000693742500012; volume:23; issue:7; firstpage:1072; lastpage:1083; numberofpages:12; journal:EUROPACE; http://hdl.handle.net/2434/907321Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85112125923 |
| DOI: | 10.1093/europace/euaa401 |
| الإتاحة: | https://doi.org/10.1093/europace/euaa401Test http://hdl.handle.net/2434/907321Test |
| حقوق: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.E81D2040 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/europace/euaa401 |
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