دورية أكاديمية
Uncovering the burden of Influenza in children in Portugal, 2008-2018
| العنوان: | Uncovering the burden of Influenza in children in Portugal, 2008-2018 |
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| المؤلفون: | Caldas Afonso, A, Gouveia, C, Januário, G, Carmo, M, Lopes, H, Bricout, H, Gomes, C, Froes, F |
| المساهمون: | Instituto de Saúde Pública da Universidade do Porto |
| بيانات النشر: | BMC |
| سنة النشر: | 2024 |
| المجموعة: | Repositório Aberto da Universidade do Porto |
| الوصف: | Background Despite their higher risk of developing severe disease, little is known about the burden of influenza in Portugal in children aged < 5 years old. This study aims to cover this gap by estimating the clinical and economic burden of severe influenza in children, in Portugal, during ten consecutive influenza seasons (2008/09-2017/18). Methods We reviewed hospitalizations in children aged < 5 years old using anonymized administrative data covering all public hospitals discharges in mainland Portugal. The burden of hospitalization and in-hospital mortality directly coded as due to influenza was supplemented by the indirect burden calculated from excess hospitalization and mortality (influenza-associated), estimated for four groups of diagnoses (pneumonia or influenza, respiratory, respiratory or cardiovascular, and all-cause), through cyclic regression models integrating the incidence of influenza. Means were reported excluding the H1N1pdm09 pandemic (2009/10). Results The mean annual number of hospitalizations coded as due to influenza was 189 (41.3 cases per 100,000 children aged < 5 years old). Hospitalization rates decreased with increasing age. Nine-in-ten children were previously healthy, but the presence of comorbidities increased with age. Children stayed, on average, 6.1 days at the hospital. Invasive mechanical ventilation was used in 2.4% of hospitalizations and non-invasive in 3.1%. Influenza-associated excess hospitalizations between 2008 and 2018 were estimated at 1,850 in pneumonia or influenza, 1,760 in respiratory, 1,787 in respiratory or cardiovascular, and 1,879 in all-cause models. A total of 95 influenza-associated excess deaths were estimated in all-cause, 14 in respiratory or cardiovascular, and 9 in respiratory models. Over ten years, influenza hospitalizations were estimated to have cost the National Health Service at least €2.9 million, of which 66.5% from healthy children. Conclusions Influenza viruses led to a high number of hospitalizations in children. Most were ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1471-2334 |
| العلاقة: | BMC Infect Dis. 2024 Jan 18;24(1):100. doi:10.1186/s12879-023-08685-z.; https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-023-08685-zTest; https://hdl.handle.net/10216/157531Test |
| DOI: | 10.1186/s12879-023-08685-z |
| الإتاحة: | https://doi.org/10.1186/s12879-023-08685-zTest https://hdl.handle.net/10216/157531Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.E80B46F8 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14712334 |
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| DOI: | 10.1186/s12879-023-08685-z |