التفاصيل البيبلوغرافية
| العنوان: |
An isocaloric nordic diet modulates rela and tnfrsf1a gene expression in peripheral blood mononuclear cells in individuals with metabolic syndrome—a sysdiet sub-study |
| المؤلفون: |
Ulven, S. M. (Stine M.), Holven, K. B. (Kirsten B.), Rundblad, A. (Amanda), Myhrstad, M. C. (Mari C. W.), Leder, L. (Lena), Dahlman, I. (Ingrid), de Mello, V. D. (Vanessa D.), Schwab, U. (Ursula), Carlberg, C. (Carsten), Pihlajamäki, J. (Jussi), Hermansen, K. (Kjeld), Dragsted, L. O. (Lars O.), Gunnarsdottir, I. (Ingibjörg), Cloetens, L. (Lieselotte), Åkesson, B. (Björn), Rosqvist, F. (Fredrik), Hukkanen, J. (Janne), Herzig, K.-H. (Karl-Heinz), Savolainen, M. J. (Markku J.), Risérus, U. (Ulf), Thorsdottir, I. (Inga), Poutanen, K. S. (Kaisa S.), Arner, P. (Peter), Uusitupa, M. (Matti), Kolehmainen, M. (Marjukka) |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2019 |
| المجموعة: |
Jultika - University of Oulu repository / Oulun yliopiston julkaisuarkisto |
| مصطلحات موضوعية: |
gene expression, inflammation, metabolic syndrome, peripheral blood mononuclear cells, randomized controlled dietary intervention |
| الوصف: |
A healthy dietary pattern is associated with a lower risk of metabolic syndrome (MetS) and reduced inflammation. To explore this at the molecular level, we investigated the effect of a Nordic diet (ND) on changes in the gene expression profiles of inflammatory and lipid-related genes in peripheral blood mononuclear cells (PBMCs) of individuals with MetS. We hypothesized that the intake of an ND compared to a control diet (CD) would alter the expression of inflammatory genes and genes involved in lipid metabolism. The individuals with MetS underwent an 18/24-week randomized intervention to compare a ND with a CD. Eighty-eight participants (66% women) were included in this sub-study of the larger SYSDIET study. Fasting PBMCs were collected before and after the intervention and changes in gene expression levels were measured using TaqMan Array Micro Fluidic Cards. Forty-eight pre-determined inflammatory and lipid related gene transcripts were analyzed. The expression level of the gene tumor necrosis factor (TNF) receptor superfamily member 1A (TNFRSF1A) was down-regulated (p = 0.004), whereas the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) subunit, RELA proto-oncogene, was up-regulated (p = 0.016) in the ND group compared to the CD group. In conclusion, intake of an ND in individuals with the MetS may affect immune function. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| الإتاحة: |
http://urn.fi/urn:nbn:fi-fe202003269411Test |
| حقوق: |
info:eu-repo/semantics/openAccess ; © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0Test/). ; https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.E77F0965 |
| قاعدة البيانات: |
BASE |
