دورية أكاديمية
The protective effect of caffeic acid phenethyl ester on cadmium-induced liver toxicity: A histopathological and biochemical study
| العنوان: | The protective effect of caffeic acid phenethyl ester on cadmium-induced liver toxicity: A histopathological and biochemical study |
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| المؤلفون: | Deveci, Hacı Ahmet, Nur, Gökhan, Kükürt, Abdulsamed, Kuru, Mushap, Deveci, Ayla |
| المساهمون: | Mühendislik ve Doğa Bilimleri Fakültesi -- Biyomedikal Mühendisliği Bölümü, Nur, Gökhan |
| بيانات النشر: | Ankara University |
| سنة النشر: | 2023 |
| المجموعة: | DSpace@ISTE (Iskenderun Technical University Institutional Repository) |
| مصطلحات موضوعية: | Cadmium, Caffeic acid phenethyl ester, Oxidant-antioxidant balance, Paraoxonase activity, Sialic acid, Cadmium Chlorides, Oxidative Stress, Testes, Veterinary Sciences, Aryldialkylphosphatase, High density lipoprotein, Low density lipoprotein, Animal experiment, Animal model, Animal tissue, Antioxidant activity, Apoptosis, Biochemical analysis, Cadmium poisoning, Controlled study, Degeneration, Enzymatic hydrolysis, Female, Histopathology, Liver cell, Liver protection, Liver tissue, Liver toxicity, Mouse, Nonhuman |
| الوصف: | In this study, the changes caused by caffeic acid phenethyl ester (CAPE) in the histopathological and biochemical parameters in the oxidant / antioxidant balance in mice with experimental cadmium toxicity were investigated. A total of 40 female Swiss albino mice were used, with 10 mice in each group. The mice were divided into four groups (Group I - Control group, Group II - CAPE group, Group III - Cadmium group, Group IV - Cadmium + CAPE group). Plasma paraoxonase (PON) activity, high-density lipoprotein (HDL), low-density lipoprotein (LDL), total sialic acid (TSA), total antioxidant capacity (TAC), total oxidant capacity (TOC), and oxidative stress index (OSI) were analyzed on mice’s blood samples. The results showed that cadmium intoxication triggered oxidative stress in the mice. It also lowered their PON activity alongside TAC and HDL levels (P<0.001, P<0.01, and P<0.01, respectively) and increased their TSA, LDL, TOC, and OSI levels (P<0.05, P<0.01, P<0.01, and P<0.01, respectively). The histopathological examination of the liver tissues revealed focal apoptotic regions, sinusoidal occlusion, and irregularity in the cadmium group and no significant change in the other groups. These results indicated that CAPE can significantly prevent biochemical and histopathological changes due to cadmium damage. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1300-0861 |
| العلاقة: | Ankara Universitesi Veteriner Fakultesi Dergisi; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; Web of Science - Scopus; Web of Science Core Collection - Science Citation Index Expanded; Deveci, H.A., Nur, G., Kükürt, A., Kuru, M., Deveci, A. (2023). The protective effect of caffeic acid phenethyl ester on cadmium-induced liver toxicity: A histopathological and biochemical study. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 70(4), 367-374. https://doi.org/10.33988/auvfd.1068527Test; https://doi.org/10.33988/auvfd.1068527Test; https://hdl.handle.net/20.500.12508/2624Test; 70; 367; 374 |
| DOI: | 10.33988/auvfd.1068527 |
| الإتاحة: | https://doi.org/20.500.12508/2624Test https://doi.org/10.33988/auvfd.1068527Test https://hdl.handle.net/20.500.12508/2624Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.E77DF1E7 |
| قاعدة البيانات: | BASE |
| تدمد: | 13000861 |
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| DOI: | 10.33988/auvfd.1068527 |